BioMedica |

Original Article

VOLUME: 38 | ISSUE: 4 | Dec 30, 2022 | PAGE: (225 - 229) | DOI: 10.24911/BioMedica/5-810

Agreement between arterial and venous blood gas measurements in patients with sepsis and septic shock

Authors: Abida Pervaiz , Sadia Bashir , Zareen Gulrohi , Usman Pasha , Xiao Ning , Khalid Mehmud Khan

Article Info

Authors

Abida Pervaiz

Senior Registrar, Department of Medicine, Jinnah Hospital Lahore, Pakistan.

ORCID

Sadia Bashir

Medical Specialist, Department of Medicine, Tehsil Head Quarter Hospital, Wazirabad, Pakistan.

Zareen Gulrohi

Senior Registrar, Department of Medicine, Avicenna Medical College & Hospital, Lahore, Pakistan.

Usman Pasha

Ph.D Scholar, School of Biochemistry & Biotechnology, University of the Punjab, Lahore, Pakistan.

Xiao Ning

Consultant Physician, Department of Medicine, Pakistan Kidney & Liver Institute and Research Centre (PKLI), Lahore, Pakistan.

Khalid Mehmud Khan

Professor, Department of Medicine, Jinnah Hospital Lahore, Pakistan.

Publication History

Received: July 21, 2022

Revised: November 24, 2022

Accepted: December 13, 2022

Published: December 30, 2022

Abstract

Background and Objective: Acid–base status is mandatory for clinical assessment of patients with septic shock and severe sepsis. Generally, venous blood gas sample collection is easier, however, the data regarding this approach are lesser defined in our population as a substitute for arterial blood gas (ABG) sample. The present study aimed to determine and compare the pH, pCO2, and bicarbonate levels in VBG and ABG samples in patients with sepsis and septic shock.

Method: A cross sectional comparative study was conducted on 350 patients with sepsis and/or septic shock admitted to the medical emergency of Jinnah Hospital, Lahore, Pakistan. Both ABG and VBG samples were collected and pH, pCO2, and bicarbonate levels were determined by standard methods. Data were analyzed using Pearson correlation and the Bland–Altman method for bias.

Results: An interclass correlation (r = 0.995, r = 0.929 and r = 0.946) was found for pH, pCO2, and bicarbonate between ABG and VBG samples, respectively. The Bland–Altman method showed a high degree of agreement for two sets of measurements; pH (bias ± SD, 0.089 ± 0.00472) and pCO2 (bias ± SD, -1.1096 ± 1.0089) with a clinically acceptable difference whereas the difference in bicarbonate measurement was found slightly higher (bias ± SD, 1.124 ± 0.674) revealing, however, a good degree of agreement with clinically acceptable bias.

Conclusion: Use of a venous blood sample in patients with sepsis or septic shock is a clinically acceptable substituent for ABG measurement in evaluating acid-base status of these patients for further management.

Keywords: Agreement, arterial blood gases, bias, sepsis, septic shock, venous blood gases

Pubmed Style

Abida Pervaiz, Sadia Bashir, Zareen Gulrohi, Usman Pasha, Xiao Ning, Khalid Mehmud Khan. Agreement between arterial and venous blood gas measurements in patients with sepsis and septic shock. BioMedica. 2023; 16 (March 2023): 225-229. doi:10.24911/BioMedica/5-810

Web Style

Abida Pervaiz, Sadia Bashir, Zareen Gulrohi, Usman Pasha, Xiao Ning, Khalid Mehmud Khan. Agreement between arterial and venous blood gas measurements in patients with sepsis and septic shock. https://biomedicapk.com/10.51441/BioMedica/5-810 [Access: March 28, 2023]. doi:10.24911/BioMedica/5-810

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Abida Pervaiz, Sadia Bashir, Zareen Gulrohi, Usman Pasha, Xiao Ning, Khalid Mehmud Khan. Agreement between arterial and venous blood gas measurements in patients with sepsis and septic shock. BioMedica. (2023), [cited March 28, 2023]; 16 (March 2023): 225-229. doi:10.24911/BioMedica/5-810

Harvard Style

Abida Pervaiz, Sadia Bashir, Zareen Gulrohi, Usman Pasha, Xiao Ning, Khalid Mehmud Khan (2023) Agreement between arterial and venous blood gas measurements in patients with sepsis and septic shock. BioMedica, 16 (March 2023): 225-229. doi:10.24911/BioMedica/5-810

Chicago Style

Abida Pervaiz, Sadia Bashir, Zareen Gulrohi, Usman Pasha, Xiao Ning, Khalid Mehmud Khan. "Agreement between arterial and venous blood gas measurements in patients with sepsis and septic shock." 16 (2023), 225-229. doi:10.24911/BioMedica/5-810

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Abida Pervaiz, Sadia Bashir, Zareen Gulrohi, Usman Pasha, Xiao Ning, Khalid Mehmud Khan (2023) Agreement between arterial and venous blood gas measurements in patients with sepsis and septic shock. , 16 (March 2023), 225-229. doi:10.24911/BioMedica/5-810