BioMedica |

Review Article

VOLUME: 38 | ISSUE: 4 | Dec 30, 2022 | PAGE: (193 - 197) | DOI: 10.24911/BioMedica/5-857

Commiphora wightii and molmol have therapeutic effects in oral cancers and COVID-19 disease by modulating anti-apoptotic proteins and inflammatory pathways

Authors: Nida Rasheed , Sarah Ghafoor

Article Info

Authors

Nida Rasheed

M. Phil. Student, Department of Oral Biology, University of Health Sciences, Lahore, Pakistan.

Sarah Ghafoor

Professor & Head, Department of Oral Biology, University of Health Sciences, Lahore, Pakistan.

ORCID

Publication History

Received: August 24, 2022

Revised: November 03, 2022

Accepted: December 05, 2022

Published: December 30, 2022

Abstract

Oral Squamous Cell Carcinoma (OSCC) has become prevalent worldwide and is one of the leading cause of death. Derangement of anti-apoptotic proteins is important regarding OSCC development. Over-expression of these proteins lead to prolonged cellular survival, thus increasing the susceptibility of tumor formation. Commiphora wightii and molmol are the natural herbs with ability to down-regulate anti-apoptotic proteins by acting on Nuclear Factor-kappa B (NF-κB) pathway, p53 pathway, signal transducer and activator of transcription pathway, estrogen, cyclooxygenase 2 and mitogen activated protein kinase pathway. NF-κB pathway has been found to involve in the release of cytokine storm associated with COVID-19 disease. Commiphora wightii and molmol suppress the COVID-19 infection by their anti-inflammatory and anti-viral properties. This review sheds light on the effect of Commiphora wightii and molmol on suppression of oral cancer and COVID-19 infection by modulation of anti-apoptotic proteins and inflammatory pathway.

Keywords: Anti-apoptotic, Commiphora molmol, Commiphora wightii, COVID-19, NF-κB, oral squamous cell carcinoma, tumor suppression

Pubmed Style

Nida Rasheed, Sarah Ghafoor. Commiphora wightii and molmol have therapeutic effects in oral cancers and COVID-19 disease by modulating anti-apoptotic proteins and inflammatory pathways. BioMedica. 2023; 16 (March 2023): 193-197. doi:10.24911/BioMedica/5-857

Web Style

Nida Rasheed, Sarah Ghafoor. Commiphora wightii and molmol have therapeutic effects in oral cancers and COVID-19 disease by modulating anti-apoptotic proteins and inflammatory pathways. https://biomedicapk.com/10.51441/BioMedica/5-857 [Access: March 28, 2023]. doi:10.24911/BioMedica/5-857

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Nida Rasheed, Sarah Ghafoor. Commiphora wightii and molmol have therapeutic effects in oral cancers and COVID-19 disease by modulating anti-apoptotic proteins and inflammatory pathways. BioMedica. (2023), [cited March 28, 2023]; 16 (March 2023): 193-197. doi:10.24911/BioMedica/5-857

Harvard Style

Nida Rasheed, Sarah Ghafoor (2023) Commiphora wightii and molmol have therapeutic effects in oral cancers and COVID-19 disease by modulating anti-apoptotic proteins and inflammatory pathways. BioMedica, 16 (March 2023): 193-197. doi:10.24911/BioMedica/5-857

Chicago Style

Nida Rasheed, Sarah Ghafoor. "Commiphora wightii and molmol have therapeutic effects in oral cancers and COVID-19 disease by modulating anti-apoptotic proteins and inflammatory pathways." 16 (2023), 193-197. doi:10.24911/BioMedica/5-857

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Nida Rasheed, Sarah Ghafoor (2023) Commiphora wightii and molmol have therapeutic effects in oral cancers and COVID-19 disease by modulating anti-apoptotic proteins and inflammatory pathways. , 16 (March 2023), 193-197. doi:10.24911/BioMedica/5-857