BioMedica |

Original Article

Volume: 41 | Issue: 1 | Published: Mar 25, 2025 | Pages: 09 - 09 | DOI: 10.24911/BioMedica/5-1222

Impending role of biomarkers of oxidative stress in myocardial infarction: a comparative study from local population

Authors: Arif Malik , Anoosh Qayyum , Jehanzaib Islam , Ayesha Zahid , Haleema Saadia , Gul Zaib

Article Info

Authors

Arif Malik

School of Pain and Regenerative Medicine, The University of Lahore, Lahore, Pakistan.

Anoosh Qayyum

Department of Biochemistry, Ameer Ud Din Medical College, Postgraduate Medical Institute, Lahore, Pakistan

Jehanzaib Islam

Department of Biological Sciences, Grand International University, Sialkot, Pakistan

Ayesha Zahid

School of Pain and Regenerative Medicine, The University of Lahore, Lahore, Pakistan

Haleema Saadia

School of Pain and Regenerative Medicine, The University of Lahore, Lahore, Pakistan

Gul Zaib

School of Pain and Regenerative Medicine, The University of Lahore, Lahore, Pakistan

ORCID

Publication History

Received: September 26, 2024

Accepted: January 09, 2025

Published: March 25, 2025

Abstract

Background and Objective: MI causes morbidity and mortality worldwide and is linked to oxidative stress and metabolic markers. This study examines how many oxidative stress markers predict myocardial infarction and its effects. Our ultimate goal is to create prognostic markers for early MI diagnosis and therapy.

Method: The University of Lahore Institute of Molecular Biology and Biotechnology researcher did a cross-sectional study. 405 clinically proven MI patients aged 20–90 were studied. The study excluded autoimmune disease and post-diagnosis surgical participants. Biochemical marker concentrations were determined using standardized ELISA kits on Lahore Teaching Hospital blood samples containing VSMCs. The study examined markers such as lipid peroxidation (DT, MDA, THB, 8-OHdG, 4-HNE, NT, IsoP-F2α) and antioxidants (SOD, Catalase).

Results: All variables demonstrated a statistically significant difference between MI patients and controls. Serum MDA levels in MI patients were higher than the control group (4.56±1.09 vs. 0.932±0.056 nmol/ml, p=0.022). In the MI group, serum oxidative stress levels (8-OHdG, 4-HNE, IsoP-F2α) were greater than in the non-MI group. Patients with MI had reduced SOD, CAT, GSH, Vitamin D, C, and E levels. 60% of MI patients smoked, 85.43% had hypertension, and 75.55% had high LDL. The group had 59% obesity and 73.82% diabetes.

Conclusion: In conclusion, oxidative stress and antioxidant enzyme levels predict myocardial infarction outcomes. Low vitamin and antioxidant levels and high MDA 4-HNE and isoprostanes levels indicate MI. The annotations show early patterns and treatment options for heart disease patients' oxidative stress.

Keywords: OS, MDA, 4-HNE, antioxidant activities, CCVR.

Pubmed Style

Arif Malik, Anoosh Qayyum, Jehanzaib Islam, Ayesha Zahid, Haleema Saadia, Gul Zaib. Impending role of biomarkers of oxidative stress in myocardial infarction: a comparative study from local population. BioMedica. 2025; 25 (March 2025): 09-09. doi:10.24911/BioMedica/5-1222

Web Style

Arif Malik, Anoosh Qayyum, Jehanzaib Islam, Ayesha Zahid, Haleema Saadia, Gul Zaib. Impending role of biomarkers of oxidative stress in myocardial infarction: a comparative study from local population. https://biomedicapk.com/index.php/articles/1222 [Access: August 10, 2025]. doi:10.24911/BioMedica/5-1222

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Arif Malik, Anoosh Qayyum, Jehanzaib Islam, Ayesha Zahid, Haleema Saadia, Gul Zaib. Impending role of biomarkers of oxidative stress in myocardial infarction: a comparative study from local population. BioMedica. (2025), [cited August 10, 2025]; 25 (March 2025): 09-09. doi:10.24911/BioMedica/5-1222

Harvard Style

Arif Malik, Anoosh Qayyum, Jehanzaib Islam, Ayesha Zahid, Haleema Saadia, Gul Zaib (2025) Impending role of biomarkers of oxidative stress in myocardial infarction: a comparative study from local population. BioMedica, 25 (March 2025): 09-09. doi:10.24911/BioMedica/5-1222

Chicago Style

Arif Malik, Anoosh Qayyum, Jehanzaib Islam, Ayesha Zahid, Haleema Saadia, Gul Zaib. "Impending role of biomarkers of oxidative stress in myocardial infarction: a comparative study from local population." 25 (2025), 09-09. doi:10.24911/BioMedica/5-1222

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Arif Malik, Anoosh Qayyum, Jehanzaib Islam, Ayesha Zahid, Haleema Saadia, Gul Zaib (2025) Impending role of biomarkers of oxidative stress in myocardial infarction: a comparative study from local population. , 25 (March 2025), 09-09. doi:10.24911/BioMedica/5-1222