Original Article

VOLUME: 36 | ISSUE: 3 | Sep 30, 2020 | PAGE: (259 - 264) | DOI: 10.24911/BioMedica/5-105

Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels


Authors: Maria Gill , Javaria Sharafat , Muhammad Usman Bashir , Rozina Noreen Hashmi , Khalid Pervez Lone , Faiza


Authors

Maria Gill

Assistant Professor, MBBS, M.Phil. Department of Physiology, CMH Institute of Medical Sciences, Multan-Pakistan

Javaria Sharafat

Department of Physiology, CMH Institute of Medical Sciences, Multan-Pakistan.

Muhammad Usman Bashir

Department of Physiology, CMH Institute of Medical Sciences, Multan-Pakistan

Rozina Noreen Hashmi

Department of Physiology, CMH Institute of Medical Sciences, Multan-Pakistan

Khalid Pervez Lone

Ex-Head of Department of Physiology University of Health Sciences, Lahore-Pakistan.

Faiza

Department of Physiology, CMH Institute of Medical Sciences, Multan-Pakistan.

Publication History

Received: March 02, 2020

Revised: July 08, 2020

Accepted: September 20, 2020

Published: September 30, 2020


Abstract


Background and Objective: Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver. Research shows that HCV infection leads to a marked reduction of serum  hepcidin levels which might be a factor in causing systemic iron overload. The present study was aimed to  determine the cause of iron overloadwhich might be due to reduced levels of serum hepcidin in chronic  hepatitis C patients.
Methods: This cross-sectional study was conducted in Department of Physiology at University of Health Sciences, Lahorefrom January 2012 to January 2014. A total of 54 male patients of chronic hepatitis C were recruited for this study and divided into two groups, group A (CHC with diabetes) and group B (CHC without diabetes). Both groupswere tested for serum hepcidin, serum iron and serum ferritin levels. ELISA technique was used to measure serum hepcidin. Serum ferritin levels were measured via CODA analyzer. Serum iron levels were measured by colorimetric method. Frequencies and percentages were calculated for serum hepcidin, serum iron and serum ferritin levels in group. The data was analyzed using SPSS (Statistical Package for Social Sciences) version 20.0. Data was considered significant where P-value was ≤ 0.05.
Results: Patients in both groups showed less serum hepcidin levelsalong with less serum iron levels in 93% cases of both groups. The patients in group A showed raisedferritin levels in 26% cases and normal ferritin levels in 63% cases. Whereas in group B 04% cases showed raisedferritin levels and 92% patients hadnormal ferritin levels; which could be a marker of ongoing chronic inflammation in CHC patients. Non-significant negative correlation was observed between serum iron and serum hepcidin inCHC population.
Conclusion: Hepatitis C virus and decreased serum iron levels in study population may be the reason of less serum hepcidin levels. Raised/normal ferritin reflects chronic inflammation in patients. Non-significant negative correlation between serum iron and serum hepcidin leads the focus towards increasing the sample size in further studies to see any significant negative correlation between studied parameters.


Keywords: Hepcidin, ferroportin, chronic hepatitis C, LEAP - (Liver antimicrobial peptide).


Pubmed Style

Maria Gill, Javaria Sharafat, Muhammad Usman Bashir, Rozina Noreen Hashmi, Khalid Pervez Lone, Faiza. Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels. BioMedica. 2020; 30 (September 2020): 259-264. doi:10.24911/BioMedica/5-105

Web Style

Maria Gill, Javaria Sharafat, Muhammad Usman Bashir, Rozina Noreen Hashmi, Khalid Pervez Lone, Faiza. Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels. https://biomedicapk.com/articles/online_first/105 [Access: May 27, 2024]. doi:10.24911/BioMedica/5-105

AMA (American Medical Association) Style

Maria Gill, Javaria Sharafat, Muhammad Usman Bashir, Rozina Noreen Hashmi, Khalid Pervez Lone, Faiza. Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels. BioMedica. 2020; 30 (September 2020): 259-264. doi:10.24911/BioMedica/5-105

Vancouver/ICMJE Style

Maria Gill, Javaria Sharafat, Muhammad Usman Bashir, Rozina Noreen Hashmi, Khalid Pervez Lone, Faiza. Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels. BioMedica. (2020), [cited May 27, 2024]; 30 (September 2020): 259-264. doi:10.24911/BioMedica/5-105

Harvard Style

Maria Gill, Javaria Sharafat, Muhammad Usman Bashir, Rozina Noreen Hashmi, Khalid Pervez Lone, Faiza (2020) Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels. BioMedica, 30 (September 2020): 259-264. doi:10.24911/BioMedica/5-105

Chicago Style

Maria Gill, Javaria Sharafat, Muhammad Usman Bashir, Rozina Noreen Hashmi, Khalid Pervez Lone, Faiza. "Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels." 30 (2020), 259-264. doi:10.24911/BioMedica/5-105

MLA (The Modern Language Association) Style

Maria Gill, Javaria Sharafat, Muhammad Usman Bashir, Rozina Noreen Hashmi, Khalid Pervez Lone, Faiza. "Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels." 30.September 2020 (2020), 259-264. Print. doi:10.24911/BioMedica/5-105

APA (American Psychological Association) Style

Maria Gill, Javaria Sharafat, Muhammad Usman Bashir, Rozina Noreen Hashmi, Khalid Pervez Lone, Faiza (2020) Serum Hepcidin Levels in Diabetic and Non-diabetic Chronic Hepatitis C Patients and Its Relation with Serum Iron Levels. , 30 (September 2020), 259-264. doi:10.24911/BioMedica/5-105