BioMedica |

Original Article

VOLUME: 36 | ISSUE: 2 | Jun 30, 2020 | PAGE: (138 - 145) | DOI: 10.24911/BioMedica/5-127

Ficus vogelii Stembarks; A Promising Herbal Remedy for Lead Induced Reproductive Toxicity

Authors: Uchewa Obinna , Augustine Egwu , Chinedu Uzomba , Emmanuel Uchewa , Ogbonna Egwu

Article Info

Authors

Uchewa Obinna

Department of Anatomy, Alex Ekwueme-Federal University Ndufu-Alike, Ikwo (FUNAI), Ebonyi State, Nigeria. PMB 1010.

Augustine Egwu

Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ikwo (AE-FUNAI), Ebonyi State, Nigeria.

Chinedu Uzomba

Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ikwo (AE-FUNAI), Ebonyi State, Nigeria.

Emmanuel Uchewa

Basic Medical Sciences, Ebonyi State University (EBSU), Abakaliki, Ebonyi State, Nigeria.

Ogbonna Egwu

Basic Medical Sciences, Ebonyi State University (EBSU), Abakaliki, Ebonyi State, Nigeria.

Publication History

Received: January 29, 2020

Revised: June 04, 2020

Accepted: June 18, 2020

Published: June 30, 2020

Abstract

Background and Objectives: Toxicity is fast becoming a major cause of infertility in this century unknowingly and researchers can no longer be mute over this situation. In this work, we aimed at exploring the potency of the bark of Ficus vogelii as an herbal product in protecting against female toxicity.
Methods: The twenty 25 female Wistar rats used weighed between 140 – 180g and were randomly assigned into five groups of five rats per group with group A servicing as control which received normal saline. Groups B and C received 3.5 mg/kg of Lead acetate 14 days and later received low and high dose of extract respectively. Group D served as lead acetate group while group E received extract only.
Results: There were changes in body, uterine and ovarian weight (P > 0.01). Superoxide Dismutase (SOD) enzyme levels were reduced significantly in B and C (P > 0.01) group animals while there was an increase in its levels in group D. Several alterations were seen in the ovary and uterus which includes reduced folliculogenesis with a marked increase in the number of atretic follicles, oedema and necrotic zones. These effects were seen to be restored near normal in the groups that were administered with extract.
Conclusions: This work showed that the bark of Ficus vogelii could be a good herbal remedy for infertility.

Keywords: Ficus vogelii, Bark, Fertility, Herbal, Lead, Toxicity.

Pubmed Style

Uchewa Obinna, Augustine Egwu, Chinedu Uzomba, Emmanuel Uchewa, Ogbonna Egwu. Ficus vogelii Stembarks; A Promising Herbal Remedy for Lead Induced Reproductive Toxicity. BioMedica. 2020; 30 (June 2020): 138-145. doi:10.24911/BioMedica/5-127

Web Style

Uchewa Obinna, Augustine Egwu, Chinedu Uzomba, Emmanuel Uchewa, Ogbonna Egwu. Ficus vogelii Stembarks; A Promising Herbal Remedy for Lead Induced Reproductive Toxicity. https://biomedicapk.com/articles/online_first/127 [Access: May 07, 2024]. doi:10.24911/BioMedica/5-127

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Uchewa Obinna, Augustine Egwu, Chinedu Uzomba, Emmanuel Uchewa, Ogbonna Egwu. Ficus vogelii Stembarks; A Promising Herbal Remedy for Lead Induced Reproductive Toxicity. BioMedica. (2020), [cited May 07, 2024]; 30 (June 2020): 138-145. doi:10.24911/BioMedica/5-127

Harvard Style

Uchewa Obinna, Augustine Egwu, Chinedu Uzomba, Emmanuel Uchewa, Ogbonna Egwu (2020) Ficus vogelii Stembarks; A Promising Herbal Remedy for Lead Induced Reproductive Toxicity. BioMedica, 30 (June 2020): 138-145. doi:10.24911/BioMedica/5-127

Chicago Style

Uchewa Obinna, Augustine Egwu, Chinedu Uzomba, Emmanuel Uchewa, Ogbonna Egwu. "Ficus vogelii Stembarks; A Promising Herbal Remedy for Lead Induced Reproductive Toxicity." 30 (2020), 138-145. doi:10.24911/BioMedica/5-127

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Uchewa Obinna, Augustine Egwu, Chinedu Uzomba, Emmanuel Uchewa, Ogbonna Egwu (2020) Ficus vogelii Stembarks; A Promising Herbal Remedy for Lead Induced Reproductive Toxicity. , 30 (June 2020), 138-145. doi:10.24911/BioMedica/5-127