Original Article
VOLUME: 36 | ISSUE: 1 | Mar 31, 2020 | PAGE: (23 - 29) | DOI: 10.24911/BioMedica/5-148
Effect of Carbonated Drinks on Uterine Development-An Experimental Study
Authors: Dr Gong Zhuandi , Professor Wei Suocheng , Wei Limin , Liang Haoqin , Lai Luju
Article Info
Authors
Dr Gong Zhuandi
Northwest University for Nationalities, Lanzhou, 730030, China
Professor Wei Suocheng
Northwest University for Nationalities, Lanzhou, 730030, China
Wei Limin
Neurology Department, People’s Hospital of Gansu Province, Lanzhou, 730030, China
Liang Haoqin
Northwest University for Nationalities, Lanzhou, 730030, China
Lai Luju
Northwest University for Nationalities, Lanzhou, 730030, China
Publication History
Received: December 25, 2019
Revised: March 08, 2020
Accepted: March 16, 2020
Published: March 31, 2020
Abstract
ABSTRACT
Background and Objective: Consumption of Coca-cola and Pepsi-cola has harmful impact on human health. Currently, scant data is available regarding effects of carbonated beverages on female reproductive system. This study was aimed to investigate the effects of carbonated beverages on uterine development and expression of follicle stimulating hormone receptor in mice model.
Methods: A total of 150 female Kunming mice weighing 20.36 ± 2.28 gm. were divided into five groups with 30 mice in each group. Groups COC-1 and COC-2 mice were given 50% and 100% Coca-cola per oral respectively for 25 days. Groups PEP-1 and PEP-2 mice were given 50% and 100% Pepsi-cola per oral respectively. Control group (CG) mice were given tap-water per oral. Western blotting was done to ascertain the levels of Follicle Stimulating Hormone Receptor (FSHR) protein in ovaries. Follicle Stimulating Hormone (FSH) levels were measured by ELISA kit.
Results: The weight of uterus in the groups COC-2 and PEP-2 was lower than that of CG. Uterine wall and uterine cavities were slightly decreased in Coca-cola and Pepsi-cola groups compared to CG. Uterine mucus was ruffled. Uterus wall thicknesses (UWT) were reduced. In comparison with CG, FSHR protein levels in COC-2 and PEP-2 groups were reduced by 21.14% and 22.80%. Serum FSH levels of COC-1, COC-2 and PEP-1 were less than that of CG. Body weights of the one-week-old mice from COC-2, PEP-1 and PEP-2 groups were increased in COC-2 and PEP-2 groups in comparison with CG (P < 0.05).
Conclusion: Oral ingestion of Coca-cola and Pepsi-cola for a longer duration reduces uterine weight, affects the uterine histology and inhibits the uterine development. reduced expression of FSHR protein may be linked with reduced growth and development of new born mice.
Keywords: Coca-cola, Pepsi-cola, Uterus, Follicle Stimulating Hormone Receptor, Mice.
Pubmed Style
Dr Gong Zhuandi, Professor Wei Suocheng, Wei Limin, Liang Haoqin, Lai Luju. Effect of Carbonated Drinks on Uterine Development-An Experimental Study. BioMedica. 2020; 31 (March 2020): 23-29. doi:10.24911/BioMedica/5-148
Web Style
Dr Gong Zhuandi, Professor Wei Suocheng, Wei Limin, Liang Haoqin, Lai Luju. Effect of Carbonated Drinks on Uterine Development-An Experimental Study. https://biomedicapk.com/articles/online_first/148 [Access: April 28, 2024]. doi:10.24911/BioMedica/5-148
AMA (American Medical Association) Style
Dr Gong Zhuandi, Professor Wei Suocheng, Wei Limin, Liang Haoqin, Lai Luju. Effect of Carbonated Drinks on Uterine Development-An Experimental Study. BioMedica. 2020; 31 (March 2020): 23-29. doi:10.24911/BioMedica/5-148
Vancouver/ICMJE Style
Dr Gong Zhuandi, Professor Wei Suocheng, Wei Limin, Liang Haoqin, Lai Luju. Effect of Carbonated Drinks on Uterine Development-An Experimental Study. BioMedica. (2020), [cited April 28, 2024]; 31 (March 2020): 23-29. doi:10.24911/BioMedica/5-148
Harvard Style
Dr Gong Zhuandi, Professor Wei Suocheng, Wei Limin, Liang Haoqin, Lai Luju (2020) Effect of Carbonated Drinks on Uterine Development-An Experimental Study. BioMedica, 31 (March 2020): 23-29. doi:10.24911/BioMedica/5-148
Chicago Style
Dr Gong Zhuandi, Professor Wei Suocheng, Wei Limin, Liang Haoqin, Lai Luju. "Effect of Carbonated Drinks on Uterine Development-An Experimental Study." 31 (2020), 23-29. doi:10.24911/BioMedica/5-148
MLA (The Modern Language Association) Style
Dr Gong Zhuandi, Professor Wei Suocheng, Wei Limin, Liang Haoqin, Lai Luju. "Effect of Carbonated Drinks on Uterine Development-An Experimental Study." 31.March 2020 (2020), 23-29. Print. doi:10.24911/BioMedica/5-148
APA (American Psychological Association) Style
Dr Gong Zhuandi, Professor Wei Suocheng, Wei Limin, Liang Haoqin, Lai Luju (2020) Effect of Carbonated Drinks on Uterine Development-An Experimental Study. , 31 (March 2020), 23-29. doi:10.24911/BioMedica/5-148