Original Article
VOLUME: 36 | ISSUE: 1 | Mar 31, 2020 | PAGE: (38 - 42) | DOI: 10.24911/BioMedica/5-150
Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study
Authors: Ponum Mirani , Gulafshan , Agha Nadeem Ahmad , Jazib Andleeb , Faiza Mehboob , Naveed Akhter
Article Info
Authors
Ponum Mirani
Multan Medical and Dental College, Multan
Gulafshan
King Edward Medical University, Lahore
Agha Nadeem Ahmad
Nishtar Medical University
Jazib Andleeb
CMH Institute of Medical Sciences, Bahawalpur
Faiza Mehboob
Multan Medical and Dental College, Multan
Naveed Akhter
Rai Medical College. Sargodha
Publication History
Received: November 19, 2019
Revised: February 06, 2020
Accepted: March 16, 2020
Published: March 31, 2020
Abstract
Background and Objective: Obesity is the adverse outcome of modern living which has affected both the physical and mental health. Slim Smart and Ultra Slim Plus are the most frequently purchased over the counter products by desperate obese persons in Pakistan having Garcinia cambogia (GC) as the main active ingredient. This study is conducted to determine the effect of GC containing Slim Smart and Ultra Slim Plus drugs on the morphology of hepatocytes in male albino mice.
Methods: Ninety albino mice were divided into control group A, experimental groups B and C receiving Slim Smart and Ultra Slim Smart respectively. Each group was further divided into subgroup I and II and the drug was administered to experimental groups for 4 and 8 weeks respectively via oral gavage. After the completion of experiment, histological examination of liver was conducted.
Results: Marked enlargement of hepatocytes was observed in experimental groups B and C (both I & II) along with ballooning degeneration and fatty change in the cytoplasm.
Conclusion: Both Slim Smart and Ultra Slim Plus has hepatotoxic effects resulting in increase in hepatocyte size, ballooning degeneration and fatty change in liver cells.
Keywords: Fatty change, Garcinia cambogia, Hydroxycitric acid, Hepatocytes, Vacuolar degeneration, Weight reducing agents.
Pubmed Style
Ponum Mirani, Gulafshan, Agha Nadeem Ahmad, Jazib Andleeb, Faiza Mehboob, Naveed Akhter. Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study. BioMedica. 2020; 31 (March 2020): 38-42. doi:10.24911/BioMedica/5-150
Web Style
Ponum Mirani, Gulafshan, Agha Nadeem Ahmad, Jazib Andleeb, Faiza Mehboob, Naveed Akhter. Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study. https://biomedicapk.com/articles/online_first/150 [Access: April 28, 2024]. doi:10.24911/BioMedica/5-150
AMA (American Medical Association) Style
Ponum Mirani, Gulafshan, Agha Nadeem Ahmad, Jazib Andleeb, Faiza Mehboob, Naveed Akhter. Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study. BioMedica. 2020; 31 (March 2020): 38-42. doi:10.24911/BioMedica/5-150
Vancouver/ICMJE Style
Ponum Mirani, Gulafshan, Agha Nadeem Ahmad, Jazib Andleeb, Faiza Mehboob, Naveed Akhter. Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study. BioMedica. (2020), [cited April 28, 2024]; 31 (March 2020): 38-42. doi:10.24911/BioMedica/5-150
Harvard Style
Ponum Mirani, Gulafshan, Agha Nadeem Ahmad, Jazib Andleeb, Faiza Mehboob, Naveed Akhter (2020) Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study. BioMedica, 31 (March 2020): 38-42. doi:10.24911/BioMedica/5-150
Chicago Style
Ponum Mirani, Gulafshan, Agha Nadeem Ahmad, Jazib Andleeb, Faiza Mehboob, Naveed Akhter. "Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study." 31 (2020), 38-42. doi:10.24911/BioMedica/5-150
MLA (The Modern Language Association) Style
Ponum Mirani, Gulafshan, Agha Nadeem Ahmad, Jazib Andleeb, Faiza Mehboob, Naveed Akhter. "Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study." 31.March 2020 (2020), 38-42. Print. doi:10.24911/BioMedica/5-150
APA (American Psychological Association) Style
Ponum Mirani, Gulafshan, Agha Nadeem Ahmad, Jazib Andleeb, Faiza Mehboob, Naveed Akhter (2020) Effect of Garcinia Cambogia Containing Co;mmercially Avaible Weight Reducing Agent on Morphology of Hepatocytes An Experimental Study. , 31 (March 2020), 38-42. doi:10.24911/BioMedica/5-150