BioMedica |

Original Article

VOLUME: 36 | ISSUE: 4 | Dec 31, 2020 | PAGE: (346 - 356) | DOI: 10.24911/BioMedica/5-78

Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines

Authors: Dandong Li , Dr. Xuhui Zhang , Linlin Li , Zhenzhen Ma , Feng Su , Tinghao Wang

Authors

Dandong Li

Joint Trauma Center, PLA 371 Center Hospital, Department of Orthopedics, 371 Hospital, Xinxiang Medical University, No.201, Wenhua Road, Xinxiang 453003, P.R. China.

Dr. Xuhui Zhang

Joint Trauma Center, PLA 371 Center Hospital, Department of Orthopedics, 371 Hospital, Xinxiang Medical University, No.201, Wenhua Road, Xinxiang 453003, P.R. China.

Linlin Li

Joint Trauma Center, PLA 371 Center Hospital, Department of Orthopedics, 371 Hospital, Xinxiang Medical University, No.201, Wenhua Road, Xinxiang 453003, P.R. China.

Zhenzhen Ma

Joint Trauma Center, PLA 371 Center Hospital, Department of Orthopedics, 371 Hospital, Xinxiang Medical University, No.201, Wenhua Road, Xinxiang 453003, P.R. China.

Feng Su

Joint Trauma Center, PLA 371 Center Hospital, Department of Orthopedics, 371 Hospital, Xinxiang Medical University, Xinxiang 453003, P.R. China

Tinghao Wang

Joint Trauma Center, PLA 371 Center Hospital, Department of Orthopedics, 371 Hospital, Xinxiang Medical University, Xinxiang 453003, P.R. China

Publication History

Received: November 09, 2020

Revised: December 01, 2020

Accepted: December 14, 2020

Published: December 31, 2020

Abstract

Background and Objective: Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by pain, morning stiffness and swelling in the knee joints. And KOA is common in the elderly and seriously affects the exercise function and physical health of patients. This study aimed to explore the curative effects of patellar inward pushing method (PIPM) on KOA.

Methods: In this study, we established rabbit animal models of KOA for the research by using the New Zealand white rabbits. A total of n=30 rabbits were divided into 5 groups by random number table method: blank group, model group, glucosamine hydrochloride (GH) group, PIPM group and PIPM combined with GH group. The rabbits were then modeled.

Results: After 9-weeks cultured in groups, 5 ml blood was collected from the heart, and cytokines were detected. The result suggested that iNOS, NO and TNF-α were the pathogenic inflammatory factor of KOA, and aggravated cartilage damage and degeneration. Besides, this study indicated that PIPM combined with GH treatment significantly reduced the activity of inflammatory cytokines in serum and joint fluid of KOA models in rabbits. In addition, PIPM combined with GH therapy exhibited the best therapeutic effect among these treatments, which was working on KOA better than PIPM treatment alone or GH treatment alone.

Conclusion: PIPM could effectively treat KOA via regulating cytokines, and the PIPM combined with GH therapy could be a novel therapeutic strategy for KOA.

Keywords: Patellar inward pushing, Knee osteoarthritis, Orthopaedic therapy, Cytokines

Pubmed Style

Dandong Li, Dr. Xuhui Zhang, Linlin Li, Zhenzhen Ma, Feng Su, Tinghao Wang. Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines. BioMedica. 2020; 31 (December 2020): 346-356. doi:10.24911/BioMedica/5-78

Web Style

Dandong Li, Dr. Xuhui Zhang, Linlin Li, Zhenzhen Ma, Feng Su, Tinghao Wang. Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines. https://biomedicapk.com/articles/online_first/78 [Access: April 29, 2024]. doi:10.24911/BioMedica/5-78

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Dandong Li, Dr. Xuhui Zhang, Linlin Li, Zhenzhen Ma, Feng Su, Tinghao Wang. Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines. BioMedica. (2020), [cited April 29, 2024]; 31 (December 2020): 346-356. doi:10.24911/BioMedica/5-78

Harvard Style

Dandong Li, Dr. Xuhui Zhang, Linlin Li, Zhenzhen Ma, Feng Su, Tinghao Wang (2020) Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines. BioMedica, 31 (December 2020): 346-356. doi:10.24911/BioMedica/5-78

Chicago Style

Dandong Li, Dr. Xuhui Zhang, Linlin Li, Zhenzhen Ma, Feng Su, Tinghao Wang. "Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines." 31 (2020), 346-356. doi:10.24911/BioMedica/5-78

MLA (The Modern Language Association) Style

Dandong Li, Dr. Xuhui Zhang, Linlin Li, Zhenzhen Ma, Feng Su, Tinghao Wang. "Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines." 31.December 2020 (2020), 346-356. Print. doi:10.24911/BioMedica/5-78

APA (American Psychological Association) Style

Dandong Li, Dr. Xuhui Zhang, Linlin Li, Zhenzhen Ma, Feng Su, Tinghao Wang (2020) Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines. , 31 (December 2020), 346-356. doi:10.24911/BioMedica/5-78