BioMedica |

Original Article

VOLUME: 35 | ISSUE: 4 | Dec 30, 2019 | PAGE: (203 - 209) | DOI: 10.51441.BioMedica.5-469

Antibacterial and Cytotoxic Activities of Ducrosia anethifolia: A Potential Biomedicine Against Selected Human Pathogens and Cancer Cell Lines

Authors: Mona Al-Whibi , Nadine M.S. Moubayed , Hajar Zahrani , Abdullah Mashhour

Article Info

Authors

Mona Al-Whibi

Science College Female Campus, King Saud University, Riyadh-Saudi Arabia.

Nadine M.S. Moubayed

Department of Microbiology, Science College, King Saud University, Riyadh-Saudi Arabia.

Hajar Zahrani

National Guard Hospital, Riyadh-Saudi Arabia.

Abdullah Mashhour

National Guard Hospital, Riyadh-Saudi Arabia.

Publication History

Received: August 15, 2019

Revised: September 30, 2019

Accepted: December 19, 2019

Published: December 30, 2019

Abstract

Background and Objective: Recently, many scientific researchers are focusing on investigating the antimicrobial activity of medicinal plants against different gram positive and gram negative bacteria as well as against some cancer cell lines as an alternative substituent to the available drugs in the market. This study was designed to investigate the chemical composition of Ducrosia anethifolia solvent extracts with their potential as antibacterial and anticancer biomedical agents
Methods: Different extracts of Ducrosia anethifolia were analyzed to reveal their major chemical composition using the gas chromatography-mass spectrometry (GC-MS). These compounds were further tested for their antibacterial (agar well diffusion technique) and cytotoxic activities (MTT assay).
Results: In-vitro antibacterial assay against selected human pathogens indicated highest susceptibility of Bacillus subtilis organic and aquatic extracts of Ducrosia fruit and leaves (15.5 mm inhibition zone) followed by Staphylococcus aureus (15mm) mainly with acetone fruit extracts. Negligible or no effect against was observed against the gram negative bacteria tested in this study. On the other hand, cytotoxic activity of methanol and water fruit and leaves Ducrosia extracts were tested on K562, HL60 and TPH1 (human adenoma leukemia) and MDA and MCF7 (human breast carcinoma) cell lines. Potent effect was recorded with water leave extract on K562 and MCF7 in a concentration varying between 4-5µl of extract/100 µl of cell line medium.
Conclusion: Potent therapeutic effect was observed with Ducrosia anethifolia crude extracts that may add further to new promising natural therapeutic agents.

Keywords: Antibacterial, Cytotoxic activity, Ducrosia anethifolia, Biomedicine, Cell lines.

Pubmed Style

Mona Al-Whibi, Nadine M.S. Moubayed, Hajar Zahrani, Abdullah Mashhour. Antibacterial and Cytotoxic Activities of Ducrosia anethifolia: A Potential Biomedicine Against Selected Human Pathogens and Cancer Cell Lines. BioMedica. 2019; 30 (December 2019): 203-209. doi:10.51441.BioMedica.5-469

Web Style

Mona Al-Whibi, Nadine M.S. Moubayed, Hajar Zahrani, Abdullah Mashhour. Antibacterial and Cytotoxic Activities of Ducrosia anethifolia: A Potential Biomedicine Against Selected Human Pathogens and Cancer Cell Lines. https://biomedicapk.com/articles/online_first/469 [Access: May 07, 2024]. doi:10.51441.BioMedica.5-469

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Mona Al-Whibi, Nadine M.S. Moubayed, Hajar Zahrani, Abdullah Mashhour. Antibacterial and Cytotoxic Activities of Ducrosia anethifolia: A Potential Biomedicine Against Selected Human Pathogens and Cancer Cell Lines. BioMedica. (2019), [cited May 07, 2024]; 30 (December 2019): 203-209. doi:10.51441.BioMedica.5-469

Harvard Style

Mona Al-Whibi, Nadine M.S. Moubayed, Hajar Zahrani, Abdullah Mashhour (2019) Antibacterial and Cytotoxic Activities of Ducrosia anethifolia: A Potential Biomedicine Against Selected Human Pathogens and Cancer Cell Lines. BioMedica, 30 (December 2019): 203-209. doi:10.51441.BioMedica.5-469

Chicago Style

Mona Al-Whibi, Nadine M.S. Moubayed, Hajar Zahrani, Abdullah Mashhour. "Antibacterial and Cytotoxic Activities of Ducrosia anethifolia: A Potential Biomedicine Against Selected Human Pathogens and Cancer Cell Lines." 30 (2019), 203-209. doi:10.51441.BioMedica.5-469

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Mona Al-Whibi, Nadine M.S. Moubayed, Hajar Zahrani, Abdullah Mashhour (2019) Antibacterial and Cytotoxic Activities of Ducrosia anethifolia: A Potential Biomedicine Against Selected Human Pathogens and Cancer Cell Lines. , 30 (December 2019), 203-209. doi:10.51441.BioMedica.5-469