BioMedica |

Original Article

VOLUME: 35 | ISSUE: 4 | Dec 30, 2019 | PAGE: (218 - 221) | DOI: 10.51441.BioMedica.5-472

Clinical Outcomes in Patients with Multi Drug Resistant Pulmonary Tuberculosis after Fixed Dose Combination Therapy of Anti-Tuberculous Drugs

Authors: Talha Laique , Naseem Saud , Asia Firdous , Ayesha Ahmad , Kamil Shujaat , Ayesha Babar , Maryam Rashid

Article Info

Authors

Talha Laique

Lahore Medical & Dental College, Lahore-Pakistan.

Naseem Saud

Sharif Medical & Dental College, Lahore-Pakistan.

Asia Firdous

INMOL Hospital, Lahore - Pakistan.

Ayesha Ahmad

Al-Nafees Medical and Dental College, Islamabad.

Kamil Shujaat

Al-Razi Medical College, Peshawar-Pakistan.

Ayesha Babar

Akhtar Saeed Medical and Dental College, Lahore-Pakistan.

Maryam Rashid

Akhtar Saeed Medical and Dental College, Lahore-Pakistan.

Publication History

Received: July 20, 2019

Revised: August 31, 2019

Accepted: December 06, 2019

Published: December 30, 2019

Abstract

Background and Objective: Tuberculosis has been an epidemic for humans over ages caused by Mycobacterium Tuberculosis (MTB). First line drugs in fixed dosage are employed for its treatment. Therefore this study was designed to observe the clinical outcomes after two months of initial treatment with antituberculous drugs in patients with pulmonary tuberculosis.
Methods: The study was conducted on n = 30 newly diagnosed patients having pulmonary tuberculosis confirmed with acid fast bacilli positive sputum at Gulab Devi Chest Hospital, Lahore. After informed written consent, blood samples were drawn at 02 and 06 hours post dose intervals for antituberculous drugs in fixed dose combination (FDC). Liver and renal enzyme levels in relation with clinical signs and symptoms were assessed and recorded before and during drug therapy on day 1, 14 &
56. Data was entered and analyzed by Statistical Package for Social Sciences (SPSS software, version 20). ANOVA test was used to determine the mean differences in laboratory parameters.
Results: Clinical improvement was seen at the end of therapy particularly in fever and weight status. Plasma levels of hepatic enzymes and renal urea and creatinine were raised (P > 0.05) however no renal and hepatic toxicity was reported.
Conclusion: Anti-tuberculous drugs as FDC were effective with improved compliance and minimal hazardous effects.

Keywords: Fixed dose combination, Pulmonary tuberculosis, Liver enzymes, Renal function, Clinical outcomes.

Pubmed Style

Talha Laique, Naseem Saud, Asia Firdous, Ayesha Ahmad, Kamil Shujaat, Ayesha Babar, Maryam Rashid. Clinical Outcomes in Patients with Multi Drug Resistant Pulmonary Tuberculosis after Fixed Dose Combination Therapy of Anti-Tuberculous Drugs. BioMedica. 2019; 30 (December 2019): 218-221. doi:10.51441.BioMedica.5-472

Web Style

Talha Laique, Naseem Saud, Asia Firdous, Ayesha Ahmad, Kamil Shujaat, Ayesha Babar, Maryam Rashid. Clinical Outcomes in Patients with Multi Drug Resistant Pulmonary Tuberculosis after Fixed Dose Combination Therapy of Anti-Tuberculous Drugs. https://biomedicapk.com/articles/online_first/472 [Access: May 08, 2024]. doi:10.51441.BioMedica.5-472

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Talha Laique, Naseem Saud, Asia Firdous, Ayesha Ahmad, Kamil Shujaat, Ayesha Babar, Maryam Rashid. Clinical Outcomes in Patients with Multi Drug Resistant Pulmonary Tuberculosis after Fixed Dose Combination Therapy of Anti-Tuberculous Drugs. BioMedica. (2019), [cited May 08, 2024]; 30 (December 2019): 218-221. doi:10.51441.BioMedica.5-472

Harvard Style

Talha Laique, Naseem Saud, Asia Firdous, Ayesha Ahmad, Kamil Shujaat, Ayesha Babar, Maryam Rashid (2019) Clinical Outcomes in Patients with Multi Drug Resistant Pulmonary Tuberculosis after Fixed Dose Combination Therapy of Anti-Tuberculous Drugs. BioMedica, 30 (December 2019): 218-221. doi:10.51441.BioMedica.5-472

Chicago Style

Talha Laique, Naseem Saud, Asia Firdous, Ayesha Ahmad, Kamil Shujaat, Ayesha Babar, Maryam Rashid. "Clinical Outcomes in Patients with Multi Drug Resistant Pulmonary Tuberculosis after Fixed Dose Combination Therapy of Anti-Tuberculous Drugs." 30 (2019), 218-221. doi:10.51441.BioMedica.5-472

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Talha Laique, Naseem Saud, Asia Firdous, Ayesha Ahmad, Kamil Shujaat, Ayesha Babar, Maryam Rashid (2019) Clinical Outcomes in Patients with Multi Drug Resistant Pulmonary Tuberculosis after Fixed Dose Combination Therapy of Anti-Tuberculous Drugs. , 30 (December 2019), 218-221. doi:10.51441.BioMedica.5-472