Review Article
VOLUME: 35 | ISSUE: 2 | Jun 24, 2019 | PAGE: (60 - 66) | DOI: 10.51441.BioMedica.5-514
Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker
Authors: Ajab Khan , Kuohai Fan , Hongquan Li
Article Info
Authors
Ajab Khan
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu-Shanxi030801.
Kuohai Fan
Experimental Teaching Center, Shanxi Agricultural University, Taigu, Shanxi 03080-P.R. China.
Hongquan Li
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu-Shanxi030801.
Publication History
Received: January 12, 2019
Revised: March 03, 2019
Accepted: June 17, 2019
Published: June 24, 2019
Abstract
Cancer is one of the major causes of morbidity and mortality to human population that leads to almost 7.6 million deaths per year globally. Invasion and migration are the main characteristics in the all types of cancers. To combat this deadly disease, prophylaxis, quick diagnosis, researching novel molecular adjuvant therapeutics or the combination of all these strategies are strictly required. Fascin, a 55 kD globular protein is expressed in the metastatic tumors and not in the normal cells. Up-regulation of Fascin has been reported in more aggressive and advanced stage of metastatic cancers. It is an indicator of poor prognosis and late stage of carcinoma. Fascin has two important actin binding sites that help in the invasion and metastasis. New molecular research is focused to inhibit its binding activity by knockdown of Fascin using short hairpin RNA (shRNA), ectopic expression of microRNAs (miRNAs), small interfering RNA (siRNA), using small fascin inhibitors, monoubiquitination and use of antimicrobial peptides. Meta-analysis and systematic review will help a lot to develop new therapeutic strategies that can inhibit tumor cell invasion and even metastatic spread of various carcinomas
Keywords: Metastatic carcinoma, Fascin, Invasion, Metastasis, MicroRNAs, Biomarker.
Pubmed Style
Ajab Khan, Kuohai Fan, Hongquan Li. Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker. BioMedica. 2019; 24 (June 2019): 60-66. doi:10.51441.BioMedica.5-514
Web Style
Ajab Khan, Kuohai Fan, Hongquan Li. Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker. https://biomedicapk.com/articles/online_first/514 [Access: May 03, 2024]. doi:10.51441.BioMedica.5-514
AMA (American Medical Association) Style
Ajab Khan, Kuohai Fan, Hongquan Li. Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker. BioMedica. 2019; 24 (June 2019): 60-66. doi:10.51441.BioMedica.5-514
Vancouver/ICMJE Style
Ajab Khan, Kuohai Fan, Hongquan Li. Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker. BioMedica. (2019), [cited May 03, 2024]; 24 (June 2019): 60-66. doi:10.51441.BioMedica.5-514
Harvard Style
Ajab Khan, Kuohai Fan, Hongquan Li (2019) Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker. BioMedica, 24 (June 2019): 60-66. doi:10.51441.BioMedica.5-514
Chicago Style
Ajab Khan, Kuohai Fan, Hongquan Li. "Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker." 24 (2019), 60-66. doi:10.51441.BioMedica.5-514
MLA (The Modern Language Association) Style
Ajab Khan, Kuohai Fan, Hongquan Li. "Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker." 24.June 2019 (2019), 60-66. Print. doi:10.51441.BioMedica.5-514
APA (American Psychological Association) Style
Ajab Khan, Kuohai Fan, Hongquan Li (2019) Advanced Molecular Inhibitory Strategies for Fascin, a Metastatic Biomarker. , 24 (June 2019), 60-66. doi:10.51441.BioMedica.5-514