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Original Article

VOLUME: 35 | ISSUE: 2 | Jun 24, 2019 | PAGE: (80 - 84) | DOI: 10.51441.BioMedica.5-521

Evaluation of Bone Density and Leptin in Thalassemic Children

Authors: Hira Soahil , Ayesha Fazal , Khalid Parvez Lone , Rizwana Kamran , Farhat Ijaz , Sahar Javed , Irum Fayyaz , Rana Khurrum

Article Info

Authors

Hira Soahil

Institute of Dentistry, CMH Lahore Medical College Lahore-Pakistan.

Ayesha Fazal

Akhtar Saeed Medical & Dental College, Lahore-Pakistan.

Khalid Parvez Lone

Department of Physiology and Cell Biology, King Edward Medical University, Lahore- Pakistan.

Rizwana Kamran

Institute of Dentistry, CMH Lahore Medical College Lahore-Pakistan.

Farhat Ijaz

Institute of Dentistry, CMH Lahore Medical College Lahore-Pakistan.

Sahar Javed

Institute of Dentistry, CMH Lahore Medical College Lahore-Pakistan.

Irum Fayyaz

Institute of Dentistry, CMH Lahore Medical College Lahore-Pakistan.

Rana Khurrum

Department of physiology, King Edward Medical University, Lahore- Pakistan.

Publication History

Received: January 02, 2019

Revised: May 15, 2019

Accepted: June 16, 2019

Published: June 24, 2019

Abstract

Background and Objective: β-thalassemia is inherited blood disorder which affects the metabolism of whole body including bones. Absence of globin chain leads to anemia which results in high serum ferritin levels. It affects the levels of serum leptin. This study is designed to evaluate serum leptin and its correlation with bone density in healthy and β-thalassemia children.
Methods: It is a comparative cross-sectional study which includes 65 normal and 65 β-thalassemia major children. Their demographic data was recorded. All children were examined for bone status with the help of Quantitative Ultrasound Bone Profiler. Z-score, Speed of Sound (Ad-SOS) and transmission time through bone (BTT) were recorded. Plasma sample was collected to determine serum Leptin level by Enzyme Immunosorbent Assay (ELISA) method.
Results: In normal children mean AD-SOS was 1906.86 ± 49.53 m/sec and of β-thalassemia major children was 1893.62 ± 57.88 m/sec. The mean serum Leptin of normal children was 3.12 ± 2.84 ng/ml and of β-thalassemia children was 1.38 ± 1.17 ng/ml.
Conclusion: Bone density is reduced in β-thalassemia children in contrast to healthy children. Serum Leptin is significantly decreased in β-thalassemia major children than in healthy controls. Positive correlation of serum leptin with bone profile was observed, though not statistically significant, which indicates that leptin deficiency is a cofactor leading to decline in bone density at early age.

Keywords: β-thalassemia major, Bone density, Leptin.

Pubmed Style

Hira Soahil, Ayesha Fazal, Khalid Parvez Lone, Rizwana Kamran, Farhat Ijaz, Sahar Javed, Irum Fayyaz, Rana Khurrum. Evaluation of Bone Density and Leptin in Thalassemic Children. BioMedica. 2019; 24 (June 2019): 80-84. doi:10.51441.BioMedica.5-521

Web Style

Hira Soahil, Ayesha Fazal, Khalid Parvez Lone, Rizwana Kamran, Farhat Ijaz, Sahar Javed, Irum Fayyaz, Rana Khurrum. Evaluation of Bone Density and Leptin in Thalassemic Children. https://biomedicapk.com/articles/online_first/521 [Access: May 03, 2024]. doi:10.51441.BioMedica.5-521

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Hira Soahil, Ayesha Fazal, Khalid Parvez Lone, Rizwana Kamran, Farhat Ijaz, Sahar Javed, Irum Fayyaz, Rana Khurrum. Evaluation of Bone Density and Leptin in Thalassemic Children. BioMedica. (2019), [cited May 03, 2024]; 24 (June 2019): 80-84. doi:10.51441.BioMedica.5-521

Harvard Style

Hira Soahil, Ayesha Fazal, Khalid Parvez Lone, Rizwana Kamran, Farhat Ijaz, Sahar Javed, Irum Fayyaz, Rana Khurrum (2019) Evaluation of Bone Density and Leptin in Thalassemic Children. BioMedica, 24 (June 2019): 80-84. doi:10.51441.BioMedica.5-521

Chicago Style

Hira Soahil, Ayesha Fazal, Khalid Parvez Lone, Rizwana Kamran, Farhat Ijaz, Sahar Javed, Irum Fayyaz, Rana Khurrum. "Evaluation of Bone Density and Leptin in Thalassemic Children." 24 (2019), 80-84. doi:10.51441.BioMedica.5-521

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Hira Soahil, Ayesha Fazal, Khalid Parvez Lone, Rizwana Kamran, Farhat Ijaz, Sahar Javed, Irum Fayyaz, Rana Khurrum (2019) Evaluation of Bone Density and Leptin in Thalassemic Children. , 24 (June 2019), 80-84. doi:10.51441.BioMedica.5-521