Original Article
VOLUME: 35 | ISSUE: 2 | Jun 24, 2019 | PAGE: (85 - 89) | DOI: 10.51441.BioMedica.5-522
Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice
Authors: Ponum Mirani , Raafea Tafweez Kuraishi , Gulafshan , Kamran Ameer , Faiza Mahboob , Rohana Rehman
Article Info
Authors
Ponum Mirani
Departments of Anatomy, King Edward Medical University, Lahore-Pakistan.
Raafea Tafweez Kuraishi
Departments of Anatomy, King Edward Medical University, Lahore-Pakistan.
Gulafshan
Departments of Anatomy, King Edward Medical University, Lahore-Pakistan.
Kamran Ameer
Associate Professor at Multan Medical and Dental College, Multan -Pakistan.
Faiza Mahboob
Departments of Anatomy, King Edward Medical University, Lahore-Pakistan.
Rohana Rehman
Oral Pathology, Multan Medical and Dental College, Multan-Pakistan.
Publication History
Received: January 03, 2019
Revised: May 23, 2019
Accepted: June 15, 2019
Published: June 24, 2019
Abstract
Background and Objective: Obesity is a rapidly growing morbidity, putting lives of the affected individuals at risk and badly affecting the quality of their life. Garcinia Cambogia is claimed to be the most effective natural ingredient present in these slimming agents. This study was designed to investigate the effects of the Garcinia Cambogia on liver histology.
Methods: Ninety male albino mice were randomly divided into three groups containing thirty mice each. Group I served as Control group and group II and III were experimental groups administered with drugs A (Slim Smart) and B (Ultra Slim Plus) respectively via oral gavage, whereas control group was only given equivalent volume of distilled water. Animals were sacrificed and liver were inspected for congestion and lymphocytic infiltration on histological examination.
Results: Histological examination revealed that group II and III had significantly larger number of inflammatory cells/HPF as compared to group I (P-value = 0.001). Group II and III were having no significant differences when compared for inflammatory cells (P-value = 0.172).Features of congestion were present in 60 (100%) animals of group II and III when compared to group I (P-value = 0.001).
Conclusion: Garcinia Cambogia containing weight reducing drugs tested in this experiment adversely affected the histology of liver. Both Slim Smart and Ultra Slim Plus have hepatotoxic effects resulting in marked cellular infiltration and congestion.
Keywords: Obesity, Pharmacological, Weight, Herbal, Garcinia Cambogia.
Pubmed Style
Ponum Mirani, Raafea Tafweez Kuraishi, Gulafshan, Kamran Ameer, Faiza Mahboob, Rohana Rehman. Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice. BioMedica. 2019; 24 (June 2019): 85-89. doi:10.51441.BioMedica.5-522
Web Style
Ponum Mirani, Raafea Tafweez Kuraishi, Gulafshan, Kamran Ameer, Faiza Mahboob, Rohana Rehman. Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice. https://biomedicapk.com/articles/online_first/522 [Access: May 03, 2024]. doi:10.51441.BioMedica.5-522
AMA (American Medical Association) Style
Ponum Mirani, Raafea Tafweez Kuraishi, Gulafshan, Kamran Ameer, Faiza Mahboob, Rohana Rehman. Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice. BioMedica. 2019; 24 (June 2019): 85-89. doi:10.51441.BioMedica.5-522
Vancouver/ICMJE Style
Ponum Mirani, Raafea Tafweez Kuraishi, Gulafshan, Kamran Ameer, Faiza Mahboob, Rohana Rehman. Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice. BioMedica. (2019), [cited May 03, 2024]; 24 (June 2019): 85-89. doi:10.51441.BioMedica.5-522
Harvard Style
Ponum Mirani, Raafea Tafweez Kuraishi, Gulafshan, Kamran Ameer, Faiza Mahboob, Rohana Rehman (2019) Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice. BioMedica, 24 (June 2019): 85-89. doi:10.51441.BioMedica.5-522
Chicago Style
Ponum Mirani, Raafea Tafweez Kuraishi, Gulafshan, Kamran Ameer, Faiza Mahboob, Rohana Rehman. "Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice." 24 (2019), 85-89. doi:10.51441.BioMedica.5-522
MLA (The Modern Language Association) Style
Ponum Mirani, Raafea Tafweez Kuraishi, Gulafshan, Kamran Ameer, Faiza Mahboob, Rohana Rehman. "Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice." 24.June 2019 (2019), 85-89. Print. doi:10.51441.BioMedica.5-522
APA (American Psychological Association) Style
Ponum Mirani, Raafea Tafweez Kuraishi, Gulafshan, Kamran Ameer, Faiza Mahboob, Rohana Rehman (2019) Effect of Over the Counter Untested Weight Reducing Agents on the Histology of Liver of Albino Mice. , 24 (June 2019), 85-89. doi:10.51441.BioMedica.5-522