BioMedica |

Original Article

VOLUME: 35 | ISSUE: 2 | Jun 24, 2019 | PAGE: (108 - 111) | DOI: 10.51441.BioMedica.5-525

Relationship of CRP Levels in Pre-Eclamptic and Normotensive with Foetal Birth Weight

Authors: Nusrat Manzoor , Aalia Tayyaba , Zafar Iqbal Bhatti , Muhammad Tauseef Rauf , Hafiz Mohammmad Dawood , Asma Saadia

Article Info

Authors

Nusrat Manzoor

Associate Professor, Department of Obstetrics and Gynaecology, Rai Medical College, Sargodha – Pakistan.

Aalia Tayyaba

Amna Inayat Medical College, Sheikhupura- Pakistan.

Zafar Iqbal Bhatti

Department of Pediatrics, Niazi Medical & Dental College, Sargodha- Pakistan.

Muhammad Tauseef Rauf

Department of Neonatology, Children Hospital, Lahore- Pakistan.

Hafiz Mohammmad Dawood

Department of Community Medicine, Sahara Medical College, Narowal– Pakistan.

Asma Saadia

Department of Pathology, Shalamar Medical & Dental College, Lahore – Pakistan.

Publication History

Received: January 15, 2019

Revised: May 20, 2019

Accepted: June 18, 2019

Published: June 24, 2019

Abstract

Background and Objectives: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality. It affects the multiple organ systems of the maternal body and may also cause preterm labour, small for gestational age infants, low birth weight, retardation and fetal growth restriction. So, the objective is to determine the level of inflammatory marker i.e. C-reactive proteins in pre-eclamptic and normotensive pregnant women and to find out its correlations with foetal birth weight.
Methods: Analytical study was conducted in the different units of Obstetrics & Gynaecology, Sir Ganga Ram Hospital, Hussain Memorial Hospital and Surraya Azeem Hospital, Lahore from February 2018 to March 2019. The study included 59 cases with preeclampsia and 59 normotensive pregnant women, all in their 3rd trimester. All the females were in the age group of 20-40 years and had a BMI range of 18-25. High sensitive C-reactive protein (hsCRP) levels were measured by Enzyme Link Immunosorbant Assay (ELISA). Statistical analysis was done using SPSS (version 15). The values were significant at the 0.05 level of significance.
Results: C-reactive protein levels were significantly high (P<0.001) in the pre-eclamptic group with a median value of 8.8 (0.3 to 24.5) as compared to 5.4 (0.24 to 9.8) mg/l in the normotensive women. The birth weight of babies was low in the pre-eclamptic group. The high CRP levels were negatively correlated with foetal birth weight in the pre-eclamptic group.
Conclusion: Elevated C-reactive protein level in pregnant women is part of an increased maternal systemic inflammatory response and correlates with low foetal birth weight.

Keywords: Pre-eclampsia, C-reactive protein, Third trimester, Birth weight.

Pubmed Style

Nusrat Manzoor, Aalia Tayyaba, Zafar Iqbal Bhatti, Muhammad Tauseef Rauf, Hafiz Mohammmad Dawood, Asma Saadia. Relationship of CRP Levels in Pre-Eclamptic and Normotensive with Foetal Birth Weight. BioMedica. 2019; 24 (June 2019): 108-111. doi:10.51441.BioMedica.5-525

Web Style

Nusrat Manzoor, Aalia Tayyaba, Zafar Iqbal Bhatti, Muhammad Tauseef Rauf, Hafiz Mohammmad Dawood, Asma Saadia. Relationship of CRP Levels in Pre-Eclamptic and Normotensive with Foetal Birth Weight. https://biomedicapk.com/articles/online_first/525 [Access: May 03, 2024]. doi:10.51441.BioMedica.5-525

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Nusrat Manzoor, Aalia Tayyaba, Zafar Iqbal Bhatti, Muhammad Tauseef Rauf, Hafiz Mohammmad Dawood, Asma Saadia. Relationship of CRP Levels in Pre-Eclamptic and Normotensive with Foetal Birth Weight. BioMedica. (2019), [cited May 03, 2024]; 24 (June 2019): 108-111. doi:10.51441.BioMedica.5-525

Harvard Style

Nusrat Manzoor, Aalia Tayyaba, Zafar Iqbal Bhatti, Muhammad Tauseef Rauf, Hafiz Mohammmad Dawood, Asma Saadia (2019) Relationship of CRP Levels in Pre-Eclamptic and Normotensive with Foetal Birth Weight. BioMedica, 24 (June 2019): 108-111. doi:10.51441.BioMedica.5-525

Chicago Style

Nusrat Manzoor, Aalia Tayyaba, Zafar Iqbal Bhatti, Muhammad Tauseef Rauf, Hafiz Mohammmad Dawood, Asma Saadia. "Relationship of CRP Levels in Pre-Eclamptic and Normotensive with Foetal Birth Weight." 24 (2019), 108-111. doi:10.51441.BioMedica.5-525

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Nusrat Manzoor, Aalia Tayyaba, Zafar Iqbal Bhatti, Muhammad Tauseef Rauf, Hafiz Mohammmad Dawood, Asma Saadia (2019) Relationship of CRP Levels in Pre-Eclamptic and Normotensive with Foetal Birth Weight. , 24 (June 2019), 108-111. doi:10.51441.BioMedica.5-525