Original Article

Volume 37, Issue 1, 2021 , Page (24 - 28)

DOI: 10.51441/BioMedica/5-166

Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block


Authors: Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar


Abstract

Background and Objecive:  Fine needle aspiration cytology of the focal liver lesions in conjunction with cell block formation offers a  convenient, less invasive and better diagnostic tool. This study was carried out to determine the diagnostic accuracy of fine-needle aspiration cytology in comparison with cell block from the aspirates taken from focal liver masses.

Methods:  This cross-sectional study was carried out over 13 months inthe Department of Pathology, Allama Iqbal Medical College Lahore, Pakistan in collaboration with the Department of Radiology, Jinnah Hospital Lahore, Pakistan. A total of 60 ultrasound-guided fine-needle aspiration cytological smears along with cell block material were collected from patients with focal liver lesions.Features of malignancy were noted on the fine-needle aspiration of liver lesions followed by cell blocks.

Results:  Cytological diagnosis based on FNAC in 59 cases was benign, out of which 39 (66.0%) were amoebic liver abscess, 14 (23.7%) were pyogenic liver abscess, 2 (3.4%) were tuberculous hepatic abscess supported by the same findings on cell block. One case (1.7%) was diagnosed as malignant on FNAC, later on, confirmed by the cell block. Four (6.7%) cases on FNAC were reported as benign lesions which were later on diagnosed as hepatocellular carcinoma on the cell block. Taking cell block as gold standard, the sensitivity, specificity, positive predictive value negative predictive value and diagnostic accuracy of FNAC was 93%, 100%, 100%, 20% and 93.3% respectively.

Conclusion:  Accurately sampled FNA smears supplemented by cell-block preparation considerably improve the false positive or negative diagnosis.


Keywords: Cytodiagnosis, Cell block, Fine needle aspiration cytology, Liver mass.


Open access Creative Commons License

Authors

Saniyah Ali

Department of Pathology Shalamar Medical & Dental college, Lahore, Pakistan.

Nausheen Henna

Ras Al Khamiah Medical & Health Sciences University, UAE

Uzma Aslam

Assistant Professor of Pathology Shalamar Medical & Dental College, Lahore, Pakistan.

Tayabba Rashid

Demonstrator, Department of Pathology Shalamar Medical & Dental College, Lahore, Pakistan.

Urfa Shafi

Associate Professor Pathology Shalamar Medical & Dental College, Lahore, Pakistan.

Naveed Akhtar

Associate Professor of Rai Medical College, Sargodha, Pakistan.

Publication History

Received: September 21, 2020

Revised: December 10, 2020

Accepted: March 10, 2021

Published: March 31, 2021

Pubmed Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. biomedica. 2021 ; 31 March 2021 ): 86-91. doi:10.51441/BioMedica/5-166

Web Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. https://biomedicapk.com/10.51441/BioMedica/5-166 [Access: June 13, 2021]. doi:10.51441/BioMedica/5-166

AMA (American Medical Association) Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. biomedica. 2021 ; 31 ( March 2021 ): 86-91. doi:10.51441/BioMedica/5-166

Vancouver/ICMJE Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. biomedica. ( 2021 ), [cited June 13, 2021]; 10 ( March 2021 ): 86-91. doi:10.51441/BioMedica/5-166

Harvard Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar ( 2021 ) Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. biomedica, 31 ( March 2021 ): 86-91. doi:10.51441/BioMedica/5-166

Turabian Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. 2021 . Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. BioMedica, 31 ( March 2021 ): 86-91. doi:10.51441/BioMedica/5-166

Chicago Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. "Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block." BioMedica 31 ( 2021 ), 86-91. doi:10.51441/BioMedica/5-166

MLA (The Modern Language Association) Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. "Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block." BioMedica 31 . March 2021 ( 2021 ), 86-91. Print. doi:10.51441/BioMedica/5-166

APA (American Psychological Association) Style

Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar ( 2021 ) Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. BioMedica, 31 ( March 2021 ), 86-91. doi:10.51441/BioMedica/5-166