Original Article

Volume 37, Issue 1, 2021 , Page (46 - 50)

DOI: 10.51441/BioMedica/5-169

Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns


Authors: Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu


Abstract

Background and objective:  Fundic gland adenocarcinoma of stomach is a distinct entity. This study investigated the clinico-pathological features, diagnosis and differential diagnosis of gastric adenocarcinoma of fundic gland type (GA-FG).

Methods:  A total of 16 cases of GA-FG were collected, their clinical characteristics were analyzed, histopathological and immunophenotypic characteristics were observed, and the relevant literature was reviewed.

Results:  There was no typical clinical manifestation of GA-FG. 16 patients were basically hospitalized with abdominal discomfort. Histopathology of GA-FG showed the diffuse multilayering and nuclear stratification with mild cytologic atypia and minimal stromal reaction even in invasive front. Conclusion: Adenocarcinoma of gastric fundus is a novel histologic type of gastric cancer. Its diagnosis is mainly based on the patho-morphological characteristics with supporting immunohistochemistry. The prognosis is good, and it needs long-term follow-up.


Keywords: Gastric neoplasms; Gastric adenocarcinoma; Fundic gland type adenocarcinoma; Low grade malignancy; Immunohistochmistry; Diagnosis.


Open access Creative Commons License

Authors

Lixin Wang

Department of Pathology, Jinhu County People's Hospital, Jiangsu Province, China.

Gang Chen

Department of Pathology, Jinhu County People's Hospital, Jiangsu Province, China.

Jingui Jiang

Department of Pathology, Jinhu County People's Hospital, Jiangsu Province, China.

Lin Li

Department of Pathology, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, China.

Ming Liang Chu

Department of Pathology, Guizhou Province People’s Hospital, Guiyang, Guizhou, China.

Publication History

Received: November 11, 2020

Revised: March 02, 2021

Accepted: March 13, 2021

Published: March 31, 2021

Pubmed Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu. Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns. biomedica. 2021 ; 31 March 2021 ): 86-91. doi:10.51441/BioMedica/5-169

Web Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu. Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns. https://biomedicapk.com/10.51441/BioMedica/5-169 [Access: June 13, 2021]. doi:10.51441/BioMedica/5-169

AMA (American Medical Association) Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu. Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns. biomedica. 2021 ; 31 ( March 2021 ): 86-91. doi:10.51441/BioMedica/5-169

Vancouver/ICMJE Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu. Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns. biomedica. ( 2021 ), [cited June 13, 2021]; 10 ( March 2021 ): 86-91. doi:10.51441/BioMedica/5-169

Harvard Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu ( 2021 ) Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns. biomedica, 31 ( March 2021 ): 86-91. doi:10.51441/BioMedica/5-169

Turabian Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu. 2021 . Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns. BioMedica, 31 ( March 2021 ): 86-91. doi:10.51441/BioMedica/5-169

Chicago Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu. "Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns." BioMedica 31 ( 2021 ), 86-91. doi:10.51441/BioMedica/5-169

MLA (The Modern Language Association) Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu. "Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns." BioMedica 31 . March 2021 ( 2021 ), 86-91. Print. doi:10.51441/BioMedica/5-169

APA (American Psychological Association) Style

Lixin Wang, Gang Chen, Jingui Jiang, Lin Li, Ming Liang Chu ( 2021 ) Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns. BioMedica, 31 ( March 2021 ), 86-91. doi:10.51441/BioMedica/5-169