Original Article

Volume 37, Issue 3 Page (1 - 10)

https://doi.org/10.51441.BioMedica.5-496

Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique


Authors: Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar


Authors

Rabia Nafees

Department of Obstetrics & Gynecology, Postgraduate Medical Institute, Ameer-Ud-Din Medical College, LGH, Lahore-Pakistan.

Yousaf Latif Khan

Department of Obstetrics & Gynecology, Postgraduate Medical Institute, Ameer-Ud-Din Medical College, LGH, Lahore-Pakistan.

Haroon Latif Khan

Lahore Institute of Fertility and Endocrinology, Lahore-Pakistan.

Aisha Awais

Lahore Institute of Fertility and Endocrinology, Lahore-Pakistan.

Nighat Mahmood

Lahore Institute of Fertility and Endocrinology, Lahore-Pakistan.

Saba Sardar

Department of Obstetrics & Gynecology, Postgraduate Medical Institute, Ameer-Ud-Din Medical College, LGH, Lahore-Pakistan.

Rameen Nisar

Department of Obstetrics & Gynecology, Postgraduate Medical Institute, Ameer-Ud-Din Medical College, LGH, Lahore-Pakistan.

Publication History

Received: September 28, 2021

Accepted:

Published: September 30, 2021


Abstract


Background & Objective: The data regarding the effectiveness of various protocols used for controlled ovarian stimulation in assisted reproductive techniques (ART)  in our own population is scant. This study comparesrecombinant follicular stimulating hormone (rFSH) and human menopausal gonadotrophins (HMG) in terms of follicular numbers and oocytes retrieved in Pakistani women undergoing ART.

Methods: A total of 300 patients were selected out of 1950 patients who visited the hospital for In Vitro Fertilization/Intra Cytoplasmic Sperm Insemination (IVF/ICSI) from June 2018 to December 2020. These patients were further divided into 2 categories: First category (1) was given long protocol and the 2nd category (2) was given short antagonist protocol. Each category was further sub-divided into two groups;  Group A who received HMG, and group B who received rFSH for controlled ovarian stimulation.

Results: There was a significantly higher number of follicles and oocytes retrieved in category 1, with recombinant FSH  (20.01±4.91, 15.19±9.18)  vs. HMG (16.07±5.67, 11.10±5.07) with a  p-value (0.00,0.004). On the other hand in category 2, the number of follicles was insignificant (p-value=0.319) in both groups. Contrary to that the number of oocytes retrieved was significantly higher with a p-value of ≤ 0.05 in both groups.

Conclusion: In controlled ovarian stimulation in ART, long protocol with rFSH has much better results both in terms of follicular numbers and retrieved oocytes. While for the short protocol with the antagonist, rFSH has been demonstrated to be superior to HMG but that is limited to the number of oocytes.


Keywords: In Vitro Fertilization, Assisted Reproductive Technology, Controlled ovarian stimulation, Human Menopausal Gonadotrophins, Recombinant Follicular Stimulating hormone



Pubmed Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar. Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique. biomedica. 2021; 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-496

Web Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar. Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique. https://biomedicapk.com/10.51441/BioMedica/5-496 [Access: October 21, 2021]. doi:10.51441.BioMedica.5-496

AMA (American Medical Association) Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar. Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique. biomedica. 2021; 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-496

Vancouver/ICMJE Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar. Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique. biomedica. (2021), [cited October 21, 2021]; 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-496

Harvard Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar (2021) Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique. biomedica, 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-496

Turabian Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar. 2021. Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique. Biomedica, 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-496

Chicago Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar. "Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique." Biomedica 30 (2021), 86-91. doi:10.51441.BioMedica.5-496

MLA (The Modern Language Association) Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar. "Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique." Biomedica 30.September 2021 (2021), 86-91. Print. doi:10.51441.BioMedica.5-496

APA (American Psychological Association) Style

Rabia Nafees, Yousaf Latif Khan, Haroon Latif Khan, Aisha Awais, Nighat Mahmood, Saba Sardar, Rameen Nisar (2021) Effect of rFSH & HMG on Oocytes number in Patients Undergoing Assisted Reproductive Technique. Biomedica, 30 (September 2021), 86-91. doi:10.51441.BioMedica.5-496