BioMedica |

Original Article

Volume: 40 | Issue: 4 | Published: Dec 25, 2024 | Pages: 159 - 163 | DOI: 10.24911/BioMedica/5-1185

Effectiveness of Creatine Supplementation among subjects with Rheumatoid Arthritis: A Randomized Controlled Trial

Authors: Aamir Usman Memon , Kumayl Abbas Meghji , Shahnaz Bano , Palwasha Abbasi , Sumayya Kazi , Muhammad Amir Memon ,

Article Info

Authors

Aamir Usman Memon

Department of Orthopedics, Suleman Roshan Medical College, Tando Adam Khan, Pakistan

Kumayl Abbas Meghji

Assistant Professor, Department of Physiology, Isra University, Hyderabad, Pakistan

Shahnaz Bano

Assistant Professor, Department of Pharmacology, Isra University, Hyderabad, Pakistan

Palwasha Abbasi

Associate Professor, Department of Pharmacology, Suleman Roshan Medical College, Tando Adam Khan, Pakistan

Sumayya Kazi

Associate Professor, Department of Biochemistry, Isra University, Hyderabad, Pakistan

Muhammad Amir Memon

Associate Professor, Department of Pediatrics, Isra University Hospital, Hyderabad, Pakistan

Publication History

Received: August 07, 2024

Accepted: December 02, 2024

Published: December 25, 2024

Abstract

Background and Objective: Creatine supplementation has shown potential benefits in improving muscle mass and strength; however, its effect in patients with rheumatoid arthritis is still under investigation. The current study aimed to evaluate the effectiveness of Creatine supplementation on body composition and physical function in the subjects presenting with rheumatoid arthritis in the local population.

Methods: A double-blinded trial involving 30 patients with RA were assigned randomly in two groups each. One group received Creatine (Cr) supplementation (Cr group) and the other, a plain flavored drink (Control group) for 12 weeks. There was no difference in appearance, odor, and color between treatment and control intervention. Assessments were conducted at the initial (pre-supplementation), on the 6th day (after the loading phase), and 12th week (immediately after supplementation ended). Demographic and clinical data were required through interviews and reviewers of medical records. Body composition parameters such as muscle, fat, and bone mass were assessed using standardized methods. Knee extensor strength and objective physical functions were evaluated using validated tests. As the data were normally distributed independent sample t test was run for between-group analysis. p < 0.05 was considered statistically significant.

Results: The study outcomes included changes in body composition and physical functioning between Cr group and the control group. A significant improvement was noted for the 8 feet up and go (80UG) test with a mean difference of 1.14 ± 0.49 (p value = 0.029). The rest of the variables including isometric knee extensor strength, sit-to-stand-30, and 50-feet Walk (500W) test showed non-significant results (p > 0.05) with a mean difference of 2.66 ± 20.65, 0.62 ± 0.56, and 1.41 ± 1.06, respectively.

Conclusion: Our findings suggest more improvement in body mass, physical functions, and knee extensor strength parameters in the Creatine supplementation group. However, the statistically significant improvement was only seen in 80UG function in the Creatine group as compared to the control. Larger scale studies are required to explore the clinical benefits of creatine supplementation in patients with rheumatoid arthritis.

Keywords: Quetelets Index, creatine, autoimmune disease, Arthritis, Rheumatoid

Pubmed Style

Aamir Usman Memon, Kumayl Abbas Meghji, Shahnaz Bano, Palwasha Abbasi, Sumayya Kazi, Muhammad Amir Memon. Effectiveness of Creatine Supplementation among subjects with Rheumatoid Arthritis: A Randomized Controlled Trial. BioMedica. 2024; 25 (December 2024): 159-163. doi:10.24911/BioMedica/5-1185

Web Style

Aamir Usman Memon, Kumayl Abbas Meghji, Shahnaz Bano, Palwasha Abbasi, Sumayya Kazi, Muhammad Amir Memon. Effectiveness of Creatine Supplementation among subjects with Rheumatoid Arthritis: A Randomized Controlled Trial. https://biomedicapk.com/articles/1185 [Access: June 23, 2025]. doi:10.24911/BioMedica/5-1185

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Aamir Usman Memon, Kumayl Abbas Meghji, Shahnaz Bano, Palwasha Abbasi, Sumayya Kazi, Muhammad Amir Memon. Effectiveness of Creatine Supplementation among subjects with Rheumatoid Arthritis: A Randomized Controlled Trial. BioMedica. (2024), [cited June 23, 2025]; 25 (December 2024): 159-163. doi:10.24911/BioMedica/5-1185

Harvard Style

Aamir Usman Memon, Kumayl Abbas Meghji, Shahnaz Bano, Palwasha Abbasi, Sumayya Kazi, Muhammad Amir Memon (2024) Effectiveness of Creatine Supplementation among subjects with Rheumatoid Arthritis: A Randomized Controlled Trial. BioMedica, 25 (December 2024): 159-163. doi:10.24911/BioMedica/5-1185

Chicago Style

Aamir Usman Memon, Kumayl Abbas Meghji, Shahnaz Bano, Palwasha Abbasi, Sumayya Kazi, Muhammad Amir Memon. "Effectiveness of Creatine Supplementation among subjects with Rheumatoid Arthritis: A Randomized Controlled Trial." 25 (2024), 159-163. doi:10.24911/BioMedica/5-1185

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Aamir Usman Memon, Kumayl Abbas Meghji, Shahnaz Bano, Palwasha Abbasi, Sumayya Kazi, Muhammad Amir Memon (2024) Effectiveness of Creatine Supplementation among subjects with Rheumatoid Arthritis: A Randomized Controlled Trial. , 25 (December 2024), 159-163. doi:10.24911/BioMedica/5-1185