Authors: Farhat Bano , Aisha Tahir , Mansoor Ghani

Abstract

Rapid emergence and spread of current pandemic of COVID-19 has evoked the medical science community to investigate quick, accurate and reliable diagnostic and prognostic approaches. Early identification of causative agent SARS-CoV-2 in host and monitoring the blood biochemical parameters for the assessment of disease severity leads to devise proper management and care to minimize mortality rate. The research studies on biochemical markers in COVID-19 published till May 15, 2020, are retrieved by using keywords “biochemical markers, biomarkers, COVID-19, and SARS-CoV-2” at web search engines (Google scholar & PubMed). Selected articles are reviewed for the selected biomarkers that can be useful prognosticators of mild and severe patient outcomes to provide assistance in clinical management of the outbreak for frontline medical personnel. Biochemical tests include panels of liver and renal functioning, lactate dehydrogenase, C-reactive protein, and interleukin-6 that have abnormal and deteriorated values as compared to normal controls and mild cases. Patients having baseline comorbidities such as hepatitis or chronic kidney disorder might develop multiorgan injuries during hospitalization but in other patients’ biomarkers measure the status of inflammatory response and drug therapy outcomes

Keywords: : SARS-CoV-2, COVID-19, Biochemical markers, Liver function tests, Renal function tests, C Reactive Protein, Interleukin-6.