Authors: WaseemU , Shahbaz M , Gul A , Baloch M.B , Munir Q , Qureshi F

Abstract

Background and Objectives: Aspirin, one of the most widely used drugs, causes deleterious effects on gastric mucosa. Anti-inflammatory properties of Acacia catechu have already been established. This study is unique as it evaluated the histopathological changes induced by aspirin in the stomach of albino rats and assessed the protective effect of different doses of Acacia catechu.
Methods: Forty eight adult albino rats, both males and female, were divided randomly into four groups A, B, C and D; each comprising of 12 rats. Group A, (control) was given chow and water ad libitum. Group B was treated with aspirin 100 mg/kg. Group C and D were given aspirin 100 mg/kg along with Acacia catechu 250 mg/kg 500 mg/kg respectively by oral route. Half of the rats from individual group were sacrificed on 3rd day and the rest on 7 th day. Stomach was examined for macroscopic (ulcer index) and microscopic (inflammatory
cells) parameters.
Results: Gross and microscopic findings on days 3 and 7 were similar. Control groups A1 and A2 showed normal healthy gastric mucosa and the least number of inflammatory cells. In group B, aspirin produced ulcerations and linear breaks; with highest ulcer index. On microscopic examination, numerous inflammatory cells were noted. Group C and D rats had minimum ulcer index and fewer inflammatory cells.
Conclusion: Aqueous solution of Acacia catechu has protective role against gastric ulcers by decreasing ulcers, and inflammation.

Keywords: Aspirin, Acacia catechu, Gastric mucosa, Non-Steroidal Anti-inflammatory Drugs, Cyclooxygenase.