Authors: Ponum Mirani , Raafea Tafweez Kuraishi , Gulafshan , Kamran Ameer , Faiza Mahboob , Rohana Rehman

Abstract

Background and Objective: Obesity is a rapidly growing morbidity, putting lives of the affected individuals at risk and badly affecting the quality of their life. Garcinia Cambogia is claimed to be the most effective natural ingredient present in these slimming agents. This study was designed to investigate the effects of the Garcinia Cambogia on liver histology.
Methods: Ninety male albino mice were randomly divided into three groups containing thirty mice each. Group I served as Control group and group II and III were experimental groups administered with drugs A (Slim Smart) and B (Ultra Slim Plus) respectively via oral gavage, whereas control group was only given equivalent volume of distilled water. Animals were sacrificed and liver were inspected for congestion and lymphocytic infiltration on histological examination.
Results: Histological examination revealed that group II and III had significantly larger number of inflammatory cells/HPF as compared to group I (P-value = 0.001). Group II and III were having no significant differences when compared for inflammatory cells (P-value = 0.172).Features of congestion were present in 60 (100%) animals of group II and III when compared to group I (P-value = 0.001).
Conclusion: Garcinia Cambogia containing weight reducing drugs tested in this experiment adversely affected the histology of liver. Both Slim Smart and Ultra Slim Plus have hepatotoxic effects resulting in marked cellular infiltration and congestion.

Keywords: Obesity, Pharmacological, Weight, Herbal, Garcinia Cambogia.