Review Article

Volume 37, Issue 3 Page (1 - 19)

https://doi.org/10.51441.BioMedica.5-498

The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges


Authors: Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli


Authors

Cui Lianxu

Department of Neurosurgery, The First People’s Hospital of Foshan, No.81 North Lingnan Road, Foshan, Guangdong - PR China.

Yasmeen Saeed

Guangdong VitaLife Biotechnology Co., LTD, No. 61 Xiannan Road, Nanhai District, Foshan, Guangdong - PR China.

Li Haomin

Department of Neurosurgery, The First People’s Hospital of Foshan, No.81 North Lingnan Road, Foshan, Guangdong - PR China.

Yang Jingli

School of Medicine, Foshan University, 18 Jiangwan Road, Foshan, Guangdong -PR China.

Publication History

Received: September 28, 2021

Accepted:

Published: September 30, 2021


Abstract


Traumatic brain injury (TBI) is a focal injury with limited reliable treatment options. Despite the large volume of basic research into TBI (particularly on the complex pathophysiology and on the application of various techniques), the treatment of TBI currently remains a challenge due to the low efficacy of available therapeutic options. Recent studies have shown that stem cells possess the ability to aid in recovery from the damaging effects of the craniocerebral injury. Herein, we attempted to present a generalized critique for the role of mesenchymal stem cell therapy in TBI, its underlying mechanisms, and the scope for improvements in TBI treatment identified through preclinical studies, clinical studies, and other research in the light of previously reported literature. Finally, we summarized some novel strategies to overcome the clinical challenges in TBI recovery. Collectively, the major objective of this review is to highlight the to-date available findings regarding role of stem cell therapy in TBI and pave the way for the development of safe and efficient regenerative treatment modalities for TBI by comprehensive understanding the specific mechanism.


Keywords: Traumatic brain injury, Mesenchymal stem cells, Stem cell therapy, Molecular mechanism, Regenerative medicine.



Pubmed Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli. The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges. biomedica. 2021; 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-498

Web Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli. The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges. https://biomedicapk.com/10.51441/BioMedica/5-498 [Access: October 21, 2021]. doi:10.51441.BioMedica.5-498

AMA (American Medical Association) Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli. The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges. biomedica. 2021; 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-498

Vancouver/ICMJE Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli. The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges. biomedica. (2021), [cited October 21, 2021]; 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-498

Harvard Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli (2021) The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges. biomedica, 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-498

Turabian Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli. 2021. The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges. Biomedica, 30 (September 2021): 86-91. doi:10.51441.BioMedica.5-498

Chicago Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli. "The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges." Biomedica 30 (2021), 86-91. doi:10.51441.BioMedica.5-498

MLA (The Modern Language Association) Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli. "The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges." Biomedica 30.September 2021 (2021), 86-91. Print. doi:10.51441.BioMedica.5-498

APA (American Psychological Association) Style

Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli (2021) The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges. Biomedica, 30 (September 2021), 86-91. doi:10.51441.BioMedica.5-498