Original Article

Volume: 41 | Issue: 2 | Published: Jun 25, 2025 | Pages: 11 - 11 | DOI: 10.24911/BioMedica/5-1235

The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis


Authors: Rabia Ahmad , Ayesha Khalid , Hira Arshad , Ahmad Saleem


Article Info

Authors

Rabia Ahmad

Associate Professor, Department of Pathology, Allama Iqbal Medical College, Jinnah Hospital Lahore, Lahore, Pakistan

Ayesha Khalid

Associate Professor, Department of Pathology, Ameer Ud Din Medical College, Lahore, Pakistan

Hira Arshad

Director Clinical Governance, Strategic Management and Internal Policy Unit, Government of Punjab, Lahore, Pakistan

Ahmad Saleem

Additional Principal Medical Officer, Department of Physiology, Allama Iqbal Medical College, Lahore, Pakistan

Publication History

Received: January 14, 2025

Accepted: May 26, 2025

Published: June 25, 2025


Abstract


Background and Objective: Bone marrow examinations are typically safe procedures. Even though complications are uncommon, they can occur and may include significant bleeding in individuals with low platelet counts and infections, usually at the skin puncture site, particularly in immunocompromised patients. The conditions examined include bone disorders, as well as both hematologic and nonhematologic malignancies in the bone marrow.

Methods: This study analysed the retrospective data from Department of Pathology, Allama Iqbal Medical College/Jinnah Hospital, Lahore, including 373 patients who underwent bone marrow trephine biopsy between January 2023 and June 2024. Patient records were reviewed for demographic and diagnostic data. Statistical analysis was performed using the chi-square test, with p < 0.05 considered significant.

Results: Of the 373 patients, 206 (55.2%) were male and 167 (44.8%) were female, yielding a male-to-female ratio of 1.2:1. The most common age group was 21-30 years, comprising 68 cases. Bone marrow aspiration was most frequently performed for suspected acute leukemia, followed by hepatosplenomegaly. Pancytopenia was observed in 59 cases (15.8%), while immune thrombocytopenia was noted in 3 cases. Normal trilineage hematopoiesis was reported in 65 cases. Aplastic anemia and hypocellular marrow were identified in 12 (3.2%) and 29 (7.7%) cases, respectively. Acute leukemia was diagnosed in 77 cases (21%), with acute myeloid leukemia (AML) accounting for 21 cases (5.6%). A statistically significant association was found between age, gender, and AML, with a higher frequency in older male patients (p = 0.04). Multiple myeloma and other plasma cell disorders were diagnosed in 3 cases (0.8%), while myelofibrosis was identified in another 3 cases (0.8%). Hemophagocytic lymphohistiocytosis, myelodysplastic syndrome, and lymphoma were seen in 3, 11, and 8 cases, respectively.

Conclusion: Acute leukemia, particularly AML, was the most frequent diagnosis on bone marrow aspiration, followed by hepatosplenomegaly and pancytopenia. Significant association of AML with older male patients underscores the need for early evaluation in this group. Bone marrow examination remains a valuable diagnostic tool for diverse hematological disorders in our setting. 


Keywords: Bone marrow, trephine biopsy, Leukemia, aplastic anemia, myelodysplastic syndrome.


Pubmed Style

Rabia Ahmad, Ayesha Khalid, Hira Arshad, Ahmad Saleem. The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis. BioMedica. 2025; 25 (June 2025): 11-11. doi:10.24911/BioMedica/5-1235

Web Style

Rabia Ahmad, Ayesha Khalid, Hira Arshad, Ahmad Saleem. The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis. https://biomedicapk.com/articles/1235 [Access: August 08, 2025]. doi:10.24911/BioMedica/5-1235

AMA (American Medical Association) Style

Rabia Ahmad, Ayesha Khalid, Hira Arshad, Ahmad Saleem. The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis. BioMedica. 2025; 25 (June 2025): 11-11. doi:10.24911/BioMedica/5-1235

Vancouver/ICMJE Style

Rabia Ahmad, Ayesha Khalid, Hira Arshad, Ahmad Saleem. The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis. BioMedica. (2025), [cited August 08, 2025]; 25 (June 2025): 11-11. doi:10.24911/BioMedica/5-1235

Harvard Style

Rabia Ahmad, Ayesha Khalid, Hira Arshad, Ahmad Saleem (2025) The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis. BioMedica, 25 (June 2025): 11-11. doi:10.24911/BioMedica/5-1235

Chicago Style

Rabia Ahmad, Ayesha Khalid, Hira Arshad, Ahmad Saleem. "The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis." 25 (2025), 11-11. doi:10.24911/BioMedica/5-1235

MLA (The Modern Language Association) Style

Rabia Ahmad, Ayesha Khalid, Hira Arshad, Ahmad Saleem. "The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis." 25.June 2025 (2025), 11-11. Print. doi:10.24911/BioMedica/5-1235

APA (American Psychological Association) Style

Rabia Ahmad, Ayesha Khalid, Hira Arshad, Ahmad Saleem (2025) The spectrum of bone marrow biopsy findings at a tertiary care Centre in Lahore: a retrospective analysis. , 25 (June 2025), 11-11. doi:10.24911/BioMedica/5-1235