Original Article
Volume: 37 | Issue: 1 | Published: Mar 31, 2021 | Pages: 24 - 28 | DOI: 10.51441/BioMedica/5-166
Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block
Authors: Saniyah Ali , Nausheen Henna , Uzma Aslam , Tayabba Rashid , Urfa Shafi , Naveed Akhtar
Article Info
Authors
Saniyah Ali
Department of Pathology Shalamar Medical & Dental college, Lahore, Pakistan.
Nausheen Henna
Ras Al Khamiah Medical & Health Sciences University, UAE
Uzma Aslam
Assistant Professor of Pathology Shalamar Medical & Dental College, Lahore, Pakistan.
Tayabba Rashid
Demonstrator, Department of Pathology Shalamar Medical & Dental College, Lahore, Pakistan.
Urfa Shafi
Associate Professor Pathology Shalamar Medical & Dental College, Lahore, Pakistan.
Naveed Akhtar
Associate Professor of Rai Medical College, Sargodha, Pakistan.
Publication History
Received: September 21, 2020
Revised: December 10, 2020
Accepted: March 10, 2021
Published: March 31, 2021
Abstract
Background and Objecive: Fine needle aspiration cytology of the focal liver lesions in conjunction with cell block formation offers a convenient, less invasive and better diagnostic tool. This study was carried out to determine the diagnostic accuracy of fine-needle aspiration cytology in comparison with cell block from the aspirates taken from focal liver masses.
Methods: This cross-sectional study was carried out over 13 months inthe Department of Pathology, Allama Iqbal Medical College Lahore, Pakistan in collaboration with the Department of Radiology, Jinnah Hospital Lahore, Pakistan. A total of 60 ultrasound-guided fine-needle aspiration cytological smears along with cell block material were collected from patients with focal liver lesions.Features of malignancy were noted on the fine-needle aspiration of liver lesions followed by cell blocks.
Results: Cytological diagnosis based on FNAC in 59 cases was benign, out of which 39 (66.0%) were amoebic liver abscess, 14 (23.7%) were pyogenic liver abscess, 2 (3.4%) were tuberculous hepatic abscess supported by the same findings on cell block. One case (1.7%) was diagnosed as malignant on FNAC, later on, confirmed by the cell block. Four (6.7%) cases on FNAC were reported as benign lesions which were later on diagnosed as hepatocellular carcinoma on the cell block. Taking cell block as gold standard, the sensitivity, specificity, positive predictive value negative predictive value and diagnostic accuracy of FNAC was 93%, 100%, 100%, 20% and 93.3% respectively.
Conclusion: Accurately sampled FNA smears supplemented by cell-block preparation considerably improve the false positive or negative diagnosis.
Keywords: Cytodiagnosis, Cell block, Fine needle aspiration cytology, Liver mass.
Pubmed Style
Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. BioMedica. 2021; 31 (March 2021): 24-28. doi:10.51441/BioMedica/5-166
Web Style
Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. https://biomedicapk.com/articles/166 [Access: December 26, 2024]. doi:10.51441/BioMedica/5-166
AMA (American Medical Association) Style
Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. BioMedica. 2021; 31 (March 2021): 24-28. doi:10.51441/BioMedica/5-166
Vancouver/ICMJE Style
Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. BioMedica. (2021), [cited December 26, 2024]; 31 (March 2021): 24-28. doi:10.51441/BioMedica/5-166
Harvard Style
Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar (2021) Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. BioMedica, 31 (March 2021): 24-28. doi:10.51441/BioMedica/5-166
Chicago Style
Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. "Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block." 31 (2021), 24-28. doi:10.51441/BioMedica/5-166
MLA (The Modern Language Association) Style
Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar. "Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block." 31.March 2021 (2021), 24-28. Print. doi:10.51441/BioMedica/5-166
APA (American Psychological Association) Style
Saniyah Ali, Nausheen Henna, Uzma Aslam, Tayabba Rashid, Urfa Shafi, Naveed Akhtar (2021) Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block. , 31 (March 2021), 24-28. doi:10.51441/BioMedica/5-166