Authors: Saba Manzoor , Rahat Abdul Rehman , Sadaqat Ijaz , Shahid Paracha , Allah Rakha

Abstract

The SARS pandemic produces new avenues to discover and anticipate the variations made in SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) and how human angiotensin converting enzyme 2 receptor ideally becomes congenial with “S” region of this virus and in consequence ofits spread in human species all over the globe. At the end of 2019, the earliest wave of SARS-CoV-2 transmission was notified from Wuhan-Hubei China and thereafter spread globally. COVID-19 infection got widespread and upto now, 2,776,224 active cases, 334,058 deceased and 2,078,505-recovered cases have been reported. Morbidity and mortality rate vary in every region which pondered the researcher to look into the linkage between a different variant of the SARS-CoV-2 with disease severity along with other determining factors like climatic changes, diagnostic techniques, hospitals and laboratory quality control measures.

Keywords: Coronavirus, COVID-19, SARS-CoV-2, Angiotensin converting enzyme 2 (ACE-2)