Original Article
Volume: 40 | Issue: 3 | Published: Sep 25, 2024 | Pages: 123 - 129 | DOI: 10.24911/BioMedica/5-1167
Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center
Authors: Mahvish Hussain , Laeeq ur Rahman , Shazia Riaz , Prof Dr Samina Zaman , Alia Ahmad , Amber Goraya
Article Info
Authors
Mahvish Hussain
Associate Professor, Dept of Histopathology, University of Child Health Sciences & The Children’s Hospital, Lahore, Pakistan
Laeeq ur Rahman
Associate Professor, Department of Neurosurgery, University of Child Health Sciences & The Children’s Hospital, Lahore, Pakistan
Shazia Riaz
Assistant Professor, Dept of Hematology & Oncology, University of Child Health Sciences & Children’s Hospital, Lahore, Pakistan
Prof Dr Samina Zaman
Professor, Department of Histopathology, University of Child Health Sciences & The Children’s Hospital, Lahore, Pakistan
Alia Ahmad
Professor , Department of Hematology & Oncology, University of Child Health Sciences & The Children’s Hospital, Lahore, Pakistan
Amber Goraya
Associate Professor, Department of Radiology, University of Child Health Sciences & The Children’s Hospital, Lahore, Pakistan
Publication History
Received: June 03, 2024
Revised: July 11, 2024
Accepted: September 10, 2024
Published: September 25, 2024
Abstract
Background and Objective: Evaluation of intraoperative frozen section (FS) in central nervous system (CNS) lesions is an invaluable tool to ensure adequacy of tissue obtained to establish the diagnosis and is consistently practiced for rapid assessment and ancillary studies. The objective of this study was to determine the diagnostic concordance between frozen section for the pediatric CNS lesions considering Histopathology as a gold standard in the local pediatric population with respect to age and gender.
Methods: This cross-sectional study was conducted at the Department of Histopathology, University of Child Health Sciences & The Children’s Hospital, Lahore, Pakistan. The biopsy specimens from 35 pediatric patients with CNS tumors were sent fresh frozen and in formalin, both, for analysis of the diagnostic accuracy of FS while taking formalin fixed paraffin embedded (FFPE) tissues as gold standard.
The data was analyzed by using statistical tests of significance.
Results: Comparing FS with FFPE tissues, 77.1 % cases showed complete concordance, 17% were partially concordant while only 5.7% cases were discordant. Male patients demonstrated higher (10.5%) discordance as compared to females (0%) (p= 0.251). Across age groups, concordance rates vary with no statistically significant differences.
Conclusion: The diagnostic concordance of frozen sections is quite higher in CNS lesions in comparison to formalin fixed paraffin embedded tissues with certain limitations occurring in different tumors. Histopathological review and clinical correlation is mandatory for reaching a conclusive diagnosis in challenging cases.
Keywords: frozen section, histopathological diagnosis, concordance
Pubmed Style
Mahvish Hussain, Laeeq ur Rahman, Shazia Riaz, Prof Dr Samina Zaman, Alia Ahmad, Amber Goraya. Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center. BioMedica. 2024; 25 (September 2024): 123-129. doi:10.24911/BioMedica/5-1167
Web Style
Mahvish Hussain, Laeeq ur Rahman, Shazia Riaz, Prof Dr Samina Zaman, Alia Ahmad, Amber Goraya. Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center. https://biomedicapk.com/articles/1167 [Access: March 25, 2025]. doi:10.24911/BioMedica/5-1167
AMA (American Medical Association) Style
Mahvish Hussain, Laeeq ur Rahman, Shazia Riaz, Prof Dr Samina Zaman, Alia Ahmad, Amber Goraya. Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center. BioMedica. 2024; 25 (September 2024): 123-129. doi:10.24911/BioMedica/5-1167
Vancouver/ICMJE Style
Mahvish Hussain, Laeeq ur Rahman, Shazia Riaz, Prof Dr Samina Zaman, Alia Ahmad, Amber Goraya. Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center. BioMedica. (2024), [cited March 25, 2025]; 25 (September 2024): 123-129. doi:10.24911/BioMedica/5-1167
Harvard Style
Mahvish Hussain, Laeeq ur Rahman, Shazia Riaz, Prof Dr Samina Zaman, Alia Ahmad, Amber Goraya (2024) Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center. BioMedica, 25 (September 2024): 123-129. doi:10.24911/BioMedica/5-1167
Chicago Style
Mahvish Hussain, Laeeq ur Rahman, Shazia Riaz, Prof Dr Samina Zaman, Alia Ahmad, Amber Goraya. "Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center." 25 (2024), 123-129. doi:10.24911/BioMedica/5-1167
MLA (The Modern Language Association) Style
Mahvish Hussain, Laeeq ur Rahman, Shazia Riaz, Prof Dr Samina Zaman, Alia Ahmad, Amber Goraya. "Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center." 25.September 2024 (2024), 123-129. Print. doi:10.24911/BioMedica/5-1167
APA (American Psychological Association) Style
Mahvish Hussain, Laeeq ur Rahman, Shazia Riaz, Prof Dr Samina Zaman, Alia Ahmad, Amber Goraya (2024) Diagnostic accuracy of frozen section in pediatric brain lesions considering histopathology as a gold standard. An experience at a Tertiary Care Center. , 25 (September 2024), 123-129. doi:10.24911/BioMedica/5-1167